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Literature summary extracted from
- Polyol-pathway enzymes of human brain. Partial purification and properties of aldose reductase and hexonate dehydrogenase (1980), Biochem. J., 187, 21-30.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.21 | 5,5-diphenylhydantoin | - |
Homo sapiens |  |
| 1.1.1.21 | Barbital | - |
Homo sapiens | |
| 1.1.1.21 | Ethosuccinimide | - |
Homo sapiens | |
| 1.1.1.21 | NADP+ | - |
Homo sapiens | |
| 1.1.1.21 | Phenobarbitone | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.21 | aldose + NAD(P)H | Homo sapiens | - |
alditol + NAD(P)+ | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.21 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.21 | partial | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.21 | brain | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.21 | 10.2 | - |
- |
Homo sapiens |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.1.1.21 | -20°C, 4 weeks, little loss of activity | Homo sapiens |
| 1.1.1.21 | 4°C, 3 weeks, 50% loss of activity | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.21 | alditol + NAD(P)+ | - |
Homo sapiens | aldose + NAD(P)H | - |
r | |
| 1.1.1.21 | aldose + NAD(P)H | - |
Homo sapiens | alditol + NAD(P)+ | - |
r | |
| 1.1.1.21 | D-glucose + NAD(P)H | - |
Homo sapiens | sorbitol + NAD(P)+ | - |
r | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.21 | 6.6 | - |
DL-glyceraldehyde + NADPH | Homo sapiens |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.21 | 5.5 | 7.5 | at pH 5.5 and pH 7.5 about 50% of activity maximum | Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.21 | NADPH | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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