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Literature summary extracted from

  • Rivett, A.J.; Smith, I.L.; Tipton, K.F.
    Purification of the high-Km aldehyde reductase from rat brain and liver and from ox brain (1981), Biochem. J., 197, 473-481.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.2 chlorpromazine
-
Bos taurus
1.1.1.2 chlorpromazine
-
Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.2 0.003 0.005 NADPH
-
Rattus norvegicus
1.1.1.2 0.037
-
Succinic semialdehyde
-
Cricetinae
1.1.1.2 0.08
-
p-nitrobenzaldehyde
-
Rattus norvegicus
1.1.1.2 0.13
-
Succinic semialdehyde
-
Rattus norvegicus
1.1.1.2 1.5
-
DL-glyceraldehyde
-
Rattus norvegicus
1.1.1.2 4.5
-
D-glucuronate
-
Rattus norvegicus
1.1.1.2 10.9
-
Succinic semialdehyde liver enzyme Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.2 30000 40000
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.2 D-glucuronate + NADPH Mus musculus
-
L-gulonate + NADP+
-
r
1.1.1.2 D-glucuronate + NADPH Homo sapiens
-
L-gulonate + NADP+
-
r
1.1.1.2 D-glucuronate + NADPH Rattus norvegicus
-
L-gulonate + NADP+
-
r
1.1.1.2 D-glucuronate + NADPH Bos taurus
-
L-gulonate + NADP+
-
r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Mus musculus
-
glycerol + NADP+
-
r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Homo sapiens
-
glycerol + NADP+
-
r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Rattus norvegicus
-
glycerol + NADP+
-
r
1.1.1.2 L-glyceraldehyde + NADPH Mus musculus
-
glycerol + NADP+
-
r
1.1.1.2 L-glyceraldehyde + NADPH Homo sapiens
-
glycerol + NADP+
-
r
1.1.1.2 L-glyceraldehyde + NADPH Rattus norvegicus
-
glycerol + NADP+
-
r
1.1.1.2 L-gulonic acid + NADP+ Rattus norvegicus
-
D-glucuronic acid + NADPH
-
r
1.1.1.2 L-gulonic acid + NADP+ Bos taurus
-
D-glucuronic acid + NADPH
-
r
1.1.1.2 succinic semialdehyde + NADPH + H+ Homo sapiens
-
4-hydroxybutyrate + NADP+
-
r
1.1.1.2 succinic semialdehyde + NADPH + H+ Rattus norvegicus
-
4-hydroxybutyrate + NADP+
-
r
1.1.1.2 succinic semialdehyde + NADPH + H+ Bos taurus
-
4-hydroxybutyrate + NADP+
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Bos taurus
-
ox
-
1.1.1.2 Cricetinae
-
-
-
1.1.1.2 Homo sapiens
-
human
-
1.1.1.2 Mus musculus
-
mouse
-
1.1.1.2 Rattus norvegicus
-
rat
-
1.1.1.2 Rattus norvegicus
-
Wistar albino
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.2
-
Rattus norvegicus
1.1.1.2
-
Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.2 brain
-
Mus musculus
-
1.1.1.2 brain
-
Homo sapiens
-
1.1.1.2 brain
-
Rattus norvegicus
-
1.1.1.2 brain
-
Bos taurus
-
1.1.1.2 brain
-
Cricetinae
-
1.1.1.2 liver
-
Mus musculus
-
1.1.1.2 liver
-
Homo sapiens
-
1.1.1.2 liver
-
Rattus norvegicus
-
1.1.1.2 liver
-
Bos taurus
-
1.1.1.2 liver
-
Cricetinae
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.2 9.59
-
high-Km aldehyde reductase from brain Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
1.1.1.2 0°C when stored frozen there is negligible loss of activity after 6 months, but repeated freezing and thawing results in loss of activity Rattus norvegicus
1.1.1.2 4°C loses activity only slowly over several weeks Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
Homo sapiens 3-pyridinemethanol + NADP+
-
r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
Rattus norvegicus 3-pyridinemethanol + NADP+
-
r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
Bos taurus 3-pyridinemethanol + NADP+
-
?
1.1.1.2 D-glucuronate + NADPH
-
Mus musculus L-gulonate + NADP+
-
?
1.1.1.2 D-glucuronate + NADPH
-
Mus musculus L-gulonate + NADP+
-
r
1.1.1.2 D-glucuronate + NADPH
-
Homo sapiens L-gulonate + NADP+
-
?
1.1.1.2 D-glucuronate + NADPH
-
Homo sapiens L-gulonate + NADP+
-
r
1.1.1.2 D-glucuronate + NADPH
-
Rattus norvegicus L-gulonate + NADP+
-
?
1.1.1.2 D-glucuronate + NADPH
-
Rattus norvegicus L-gulonate + NADP+
-
r
1.1.1.2 D-glucuronate + NADPH
-
Bos taurus L-gulonate + NADP+
-
?
1.1.1.2 D-glucuronate + NADPH
-
Bos taurus L-gulonate + NADP+
-
r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
Mus musculus glycerol + NADP+
-
r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
Homo sapiens glycerol + NADP+
-
r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
Rattus norvegicus glycerol + NADP+
-
r
1.1.1.2 glycerol + NADP+
-
Rattus norvegicus DL-glyceraldehyde + NADPH + H+
-
?
1.1.1.2 L-glyceraldehyde + NADPH
-
Mus musculus glycerol + NADP+
-
r
1.1.1.2 L-glyceraldehyde + NADPH
-
Homo sapiens glycerol + NADP+
-
r
1.1.1.2 L-glyceraldehyde + NADPH
-
Rattus norvegicus glycerol + NADP+
-
r
1.1.1.2 L-gulonic acid + NADP+
-
Rattus norvegicus D-glucuronic acid + NADPH
-
r
1.1.1.2 L-gulonic acid + NADP+
-
Bos taurus D-glucuronic acid + NADPH
-
r
1.1.1.2 L-gulonic acid + NADPH
-
Rattus norvegicus D-glucuronic acid + NADP+
-
r
1.1.1.2 L-gulonic acid + NADPH
-
Bos taurus D-glucuronic acid + NADP+
-
r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
Homo sapiens p-nitrobenzylalcohol + NADP+
-
r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
Rattus norvegicus p-nitrobenzylalcohol + NADP+
-
r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
Bos taurus p-nitrobenzylalcohol + NADP+
-
r
1.1.1.2 succinic semialdehyde + NADPH + H+
-
Homo sapiens 4-hydroxybutyrate + NADP+
-
r
1.1.1.2 succinic semialdehyde + NADPH + H+
-
Rattus norvegicus 4-hydroxybutyrate + NADP+
-
r
1.1.1.2 succinic semialdehyde + NADPH + H+
-
Bos taurus 4-hydroxybutyrate + NADP+
-
r
1.1.1.2 succinic semialdehyde + NADPH + H+
-
Cricetinae 4-hydroxybutyrate + NADP+
-
r

Subunits

EC Number Subunits Comment Organism
1.1.1.2 monomer
-
Homo sapiens
1.1.1.2 monomer
-
Rattus norvegicus
1.1.1.2 monomer
-
Bos taurus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.1.1.2 40 50 at 40°C for 10 min enzyme retains about 90% of its activity towards D-glucuronate, after 10 min at 50% activity decreases to less than 5% Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.2 5.8 8
-
Rattus norvegicus

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
1.1.1.2 6 8
-
Rattus norvegicus