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Literature summary extracted from

  • Branlant, G.M; Biellmann, J.F.
    Purification and some properties of aldehyde reductases from pig liver (1980), Eur. J. Biochem., 105, 611-621.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.2 medicine
-
 Rattus norvegicus
1.1.1.2 medicine daunorubicin, a cancer chemotherapeutic agent can be reduced by aldehyde reductase Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.2 1,10-phenanthroline
-
 Sus scrofa
1.1.1.2 2-mercaptoethanol
-
 Sus scrofa
1.1.1.2 NADPH competitive inhibitor for reductase I Sus scrofa
1.1.1.2 Phenobarbital
-
 Rattus norvegicus
1.1.1.2 Phenobarbital
-
 Sus scrofa
1.1.1.2 pyrazole
-
 Equus sp.
1.1.1.2 pyrazole
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.2 0.0056
-
 NADPH
-
 Sus scrofa
1.1.1.2 0.008
-
 NADPH
-
 Sus scrofa
1.1.1.2 0.05
-
 p-Carboxybenzaldehyde
-
 Sus scrofa
1.1.1.2 0.08
-
 daunorubicin reductase I Sus scrofa
1.1.1.2 0.1
-
 4-Carboxyphenylglyoxal
-
 Sus scrofa
1.1.1.2 0.1
-
 Succinic semialdehyde reductase I Sus scrofa
1.1.1.2 0.27
-
 p-nitrobenzaldehyde
-
 Sus scrofa
1.1.1.2 0.6
-
 indolacetaldehyde
-
 Sus scrofa
1.1.1.2 1.2
-
 Phenylglyoxal
-
 Sus scrofa
1.1.1.2 1.5
-
 D-glucuronate
-
 Sus scrofa
1.1.1.2 1.5
-
 3-Pyridinecarboxaldehyde
-
 Sus scrofa
1.1.1.2 1.6
-
 4-Carboxyacetophenone
-
 Sus scrofa
1.1.1.2 2
-
 2-chloroheptanal
-
 Sus scrofa
1.1.1.2 4.5
-
 D-glyceraldehyde
-
 Sus scrofa
1.1.1.2 10
-
 Heptanal
-
 Sus scrofa
1.1.1.2 10
-
 p-nitroacetophenone
-
 Sus scrofa
1.1.1.2 14
-
 butane 2,3-dione
-
 Sus scrofa
1.1.1.2 150
-
 n-Butyraldehyde
-
 Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.2 34000
-
 liver enzyme, aldehyde reductase I, gel filtration Sus scrofa
1.1.1.2 35000
-
 liver enzyme, reductase II, gel filtration Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.2 D-glucuronate + NADPH Mus musculus
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Rattus norvegicus
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Sus scrofa
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Ovis aries
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Mus musculus
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Rattus norvegicus
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Sus scrofa
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Ovis aries
-
 glycerol + NADP+
-
 r
1.1.1.2 L-gulonic acid + NADP+ Rattus norvegicus
-
 D-glucuronic acid + NADPH
-
 r
1.1.1.2 L-gulonic acid + NADP+ Sus scrofa
-
 D-glucuronic acid + NADPH
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+ Rattus norvegicus
-
 4-hydroxybutyrate + NADP+
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+ Sus scrofa
-
 4-hydroxybutyrate + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Equus sp.
-
 horse
-
1.1.1.2 Mus musculus
-
 mouse
-
1.1.1.2 Ovis aries
-
 sheep
-
1.1.1.2 Ovis aries
-
 Suffolk-Hampshire
-
1.1.1.2 Rattus norvegicus
-
 rat
-
1.1.1.2 Sus scrofa
-
 pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.2
-
 Rattus norvegicus
1.1.1.2 aldehyde reductase I Ovis aries
1.1.1.2 aldehyde reductase I and II from brain, no recuctase II activity could be detected in pig kidney Sus scrofa
1.1.1.2 reductase I Equus sp.

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.2 brain
-
 Mus musculus
-
1.1.1.2 brain
-
 Rattus norvegicus
-
1.1.1.2 brain
-
 Sus scrofa
-
1.1.1.2 brain
-
 Ovis aries
-
1.1.1.2 kidney
-
 Mus musculus
-
1.1.1.2 kidney
-
 Rattus norvegicus
-
1.1.1.2 kidney
-
 Sus scrofa
-
1.1.1.2 kidney
-
 Ovis aries
-
1.1.1.2 liver
-
 Mus musculus
-
1.1.1.2 liver
-
 Rattus norvegicus
-
1.1.1.2 liver
-
 Sus scrofa
-
1.1.1.2 liver
-
 Ovis aries
-
1.1.1.2 liver
-
 Equus sp.
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.2 35
-
-
 Sus scrofa

Storage Stability

EC Number Storage Stability Organism
1.1.1.2 -20°C, stable for several months if stored as an ammonium sulfate precipitate Sus scrofa
1.1.1.2 20°C reductase I stable for more than 1 month Sus scrofa
1.1.1.2 4°C reductase I and II are stable for several months Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 2-chloroheptanal + NADPH
-
 Sus scrofa 2-chloroheptanol + NADP+
-
 r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Rattus norvegicus 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Sus scrofa 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Ovis aries 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 4-carboxyacetophenone + NADPH
-
 Sus scrofa ? + NADP+
-
 r
1.1.1.2 4-carboxyphenylglyoxal + NADPH
-
 Sus scrofa ? + NADP+
-
 r
1.1.1.2 benzyl alcohol + NADP+
-
 Sus scrofa benzaldehyde + NADPH
-
 r
1.1.1.2 butane 2,3-dione + NADPH
-
 Sus scrofa ? + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Mus musculus L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Mus musculus L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Rattus norvegicus L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Rattus norvegicus L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Sus scrofa L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Sus scrofa L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Ovis aries L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Ovis aries L-gulonate + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Mus musculus glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Rattus norvegicus glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Sus scrofa glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Ovis aries glycerol + NADP+
-
 r
1.1.1.2 daunorubicin + NADPH
-
 Rattus norvegicus ? + NADP+
-
 ?
1.1.1.2 daunorubicin + NADPH
-
 Sus scrofa ? + NADP+
-
 ?
1.1.1.2 indol-3-ylacetaldehyde + NADPH
-
 Sus scrofa indol-3-ethanol + NADP+
-
 ?
1.1.1.2 indolacetaldehyde + NADPH
-
 Sus scrofa ? + NADP+
-
 ?
1.1.1.2 L-gulonic acid + NADP+
-
 Rattus norvegicus D-glucuronic acid + NADPH
-
 r
1.1.1.2 L-gulonic acid + NADP+
-
 Sus scrofa D-glucuronic acid + NADPH
-
 r
1.1.1.2 L-gulonic acid + NADPH
-
 Rattus norvegicus D-glucuronic acid + NADP+
-
 r
1.1.1.2 L-gulonic acid + NADPH
-
 Sus scrofa D-glucuronic acid + NADP+
-
 r
1.1.1.2 n-butyraldehyde + NADPH
-
 Sus scrofa n-butanol + NADP+
-
 ?
1.1.1.2 n-heptanal + NADPH
-
 Sus scrofa heptanol + NADP+
-
 r
1.1.1.2 p-carboxybenzaldehyde + NADPH
-
 Rattus norvegicus p-carboxybenzyl alcohol + NADP+
-
 r
1.1.1.2 p-carboxybenzaldehyde + NADPH
-
 Sus scrofa p-carboxybenzyl alcohol + NADP+
-
 r
1.1.1.2 p-nitroacetophenone + NADPH
-
 Sus scrofa ? + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Rattus norvegicus p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Sus scrofa p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Ovis aries p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 phenylglyoxal + NADPH
-
 Sus scrofa ? + NADP+
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+
-
 Rattus norvegicus 4-hydroxybutyrate + NADP+
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+
-
 Sus scrofa 4-hydroxybutyrate + NADP+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.2 monomer
-
 Rattus norvegicus
1.1.1.2 monomer 1 * 35000 Sus scrofa

Synonyms

EC Number Synonyms Comment Organism
1.1.1.2 liver alcohol dehydrogenase
-
 Equus sp.

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.2 5.9
-
 aldehyde reductase I Sus scrofa
1.1.1.2 6.2
-
 aldehyde reductase II Sus scrofa