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Literature summary extracted from

  • Turner, A.J.; Tipton, K.F.
    The characterization of two reduced nicotinamide-adenine dinucleotide phosphate-linked aldehyde reductases from pig brain (1972), Biochem. J., 130, 765-772.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.2 chlorpromazine
-
 Bos taurus
1.1.1.2 chlorpromazine
-
 Rattus norvegicus
1.1.1.2 chlorpromazine
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.2 0.0007
-
 p-hydroxyphenylglycolaldehyde low-Km reductase Sus scrofa
1.1.1.2 0.0012
-
 NADPH low-Km reductase Sus scrofa
1.1.1.2 0.0013
-
 p-nitrobenzaldehyde low-Km reductase Sus scrofa
1.1.1.2 0.0023
-
 p-hydroxyphenylacetaldehyde low-Km reductase Sus scrofa
1.1.1.2 0.0038
-
 hydroxyindol-3-ylacetaldehyde low-Km reductase Sus scrofa
1.1.1.2 0.004
-
 p-nitrobenzaldehyde low-Km aldehyde reductase Sus scrofa
1.1.1.2 0.0059
-
 indol-3-ylacetaldehyde low-Km reductase Sus scrofa
1.1.1.2 0.2
-
 indol-3-ylacetaldehyde high-Km aldehyde reductase Sus scrofa
1.1.1.2 0.25
-
 NADPH high-Km aldehyde reductase Sus scrofa
1.1.1.2 0.25
-
 p-nitrobenzaldehyde high-Km aldehyde reductase Sus scrofa
1.1.1.2 0.29
-
 p-nitrobenzaldehyde high-Km aldehyde reductase Sus scrofa
1.1.1.2 0.65
-
 p-hydroxyphenylglycolaldehyde high-Km aldehyde reductase Sus scrofa
1.1.1.2 0.85
-
 p-hydroxyphenylacetaldehyde high-Km aldehyde reductase Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.2 29000
-
 gel filtration, high-Km reductase Sus scrofa
1.1.1.2 30200
-
-
 Sus scrofa
1.1.1.2 36000
-
 gel filtration, low-Km reductase Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Bos taurus
-
 ox
-
1.1.1.2 Rattus norvegicus
-
 rat
-
1.1.1.2 Sus scrofa
-
 pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.2
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.2 brain
-
 Rattus norvegicus
-
1.1.1.2 brain
-
 Sus scrofa
-
1.1.1.2 brain
-
 Bos taurus
-
1.1.1.2 liver
-
 Rattus norvegicus
-
1.1.1.2 liver
-
 Sus scrofa
-
1.1.1.2 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.2 0.008
-
 low-Km reductase Sus scrofa
1.1.1.2 0.05
-
-
 Bos taurus
1.1.1.2 0.34
-
 high-Km reductase Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 4-hydroxy-3-methoxyphenethylene glycol + NADP+
-
 Sus scrofa ? + NADPH
-
 r
1.1.1.2 hydroxyindol-3-ylacetaldehyde + NADPH
-
 Sus scrofa ? + NADP+
-
 r
1.1.1.2 indol-3-ylacetaldehyde + NADPH
-
 Sus scrofa indol-3-ethanol + NADP+
-
 r
1.1.1.2 additional information
-
 Bos taurus ?
-
 ?
1.1.1.2 additional information 5-hydroxyindol-3-ylacetaldehyde is no substrate Sus scrofa ?
-
 ?
1.1.1.2 p-hydroxyphenylacetaldehyde + NADPH + H+
-
 Rattus norvegicus p-hydroxyphenylethanol + NADP+
-
 r
1.1.1.2 p-hydroxyphenylacetaldehyde + NADPH + H+
-
 Sus scrofa p-hydroxyphenylethanol + NADP+
-
 r
1.1.1.2 p-hydroxyphenylacetaldehyde + NADPH + H+
-
 Bos taurus p-hydroxyphenylethanol + NADP+
-
 r
1.1.1.2 p-hydroxyphenylglycolaldehyde + NADPH
-
 Rattus norvegicus 4-hydroxyphenylethylalcohol + NADP+
-
 r
1.1.1.2 p-hydroxyphenylglycolaldehyde + NADPH
-
 Sus scrofa 4-hydroxyphenylethylalcohol + NADP+
-
 r
1.1.1.2 p-hydroxyphenylglycolaldehyde + NADPH
-
 Bos taurus 4-hydroxyphenylethylalcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Rattus norvegicus p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH cofactor NADPH Sus scrofa p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH cofactor NADPH Bos taurus p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 propane-1,2-diol + NADP+
-
 Sus scrofa lactaldehyde + NADPH
-
 r
1.1.1.2 propane-1,2-diol + NADP+
-
 Bos taurus lactaldehyde + NADPH
-
 r