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Literature summary extracted from

  • Bosron, W.F.; Prairie, R.L.
    Triphosphopyridine nucleotide-linked aldehyde reductase I. Purification and properties of the enzyme from pig kidney cortex (1972), J. Biol. Chem., 217, 4480-4485.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.2 PO43- stimulates the enzymatic reduction of 3-pyridinecarboxaldehyde Sus scrofa
1.1.1.2 SO42- stimulates the enzymatic reduction of 3-pyridinecarboxaldehyde Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.2 Amobarbital
-
Sus scrofa
1.1.1.2 hydroxylamine
-
Sus scrofa
1.1.1.2 iodoacetic acid
-
Sus scrofa
1.1.1.2 Sodium fluoride
-
Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.2 0.078
-
p-Carboxybenzaldehyde
-
Sus scrofa
1.1.1.2 0.33
-
(+)-Camphorquinone
-
Sus scrofa
1.1.1.2 0.35
-
p-nitrobenzaldehyde
-
Sus scrofa
1.1.1.2 0.51
-
p-cyanobenzaldehyde
-
Sus scrofa
1.1.1.2 0.69
-
4-Pyridinecarboxaldehyde
-
Sus scrofa
1.1.1.2 2.6
-
3-Pyridinecarboxaldehyde
-
Sus scrofa
1.1.1.2 5.5
-
3-Pyridinemethanol
-
Sus scrofa
1.1.1.2 775
-
glycerol
-
Sus scrofa
1.1.1.2 1360
-
L-arabitol
-
Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.2 25000
-
gel filtration, ultracentrifugation, specific activity corresponding to molecular weight Sus scrofa
1.1.1.2 30200
-
gel filtration, sedimentation equilibrium determination Sus scrofa
1.1.1.2 38000
-
1 * 38000, SDS-PAGE Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.2 alpha-diketone + NADPH Sus scrofa
-
? + NADP+
-
?
1.1.1.2 D-glucuronate + NADPH Rattus norvegicus
-
L-gulonate + NADP+
-
r
1.1.1.2 D-glucuronate + NADPH Sus scrofa
-
L-gulonate + NADP+
-
r
1.1.1.2 D-glucuronate + NADPH Bos taurus
-
L-gulonate + NADP+
-
r
1.1.1.2 D-glucuronate + NADPH Oryctolagus cuniculus
-
L-gulonate + NADP+
-
r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Rattus norvegicus
-
glycerol + NADP+
-
r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Sus scrofa
-
glycerol + NADP+
-
r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Oryctolagus cuniculus
-
glycerol + NADP+
-
r
1.1.1.2 L-gulonic acid + NADP+ Rattus norvegicus
-
D-glucuronic acid + NADPH
-
r
1.1.1.2 L-gulonic acid + NADP+ Sus scrofa
-
D-glucuronic acid + NADPH
-
r
1.1.1.2 L-gulonic acid + NADP+ Bos taurus
-
D-glucuronic acid + NADPH
-
r
1.1.1.2 L-gulonic acid + NADP+ Oryctolagus cuniculus
-
D-glucuronic acid + NADPH
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Bos taurus
-
bovine
-
1.1.1.2 Oryctolagus cuniculus
-
rabbit
-
1.1.1.2 Rattus norvegicus
-
rat
-
1.1.1.2 Sus scrofa
-
pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.2
-
Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.2 kidney
-
Rattus norvegicus
-
1.1.1.2 kidney
-
Bos taurus
-
1.1.1.2 kidney cortex Sus scrofa
-
1.1.1.2 kidney cortex Oryctolagus cuniculus
-
1.1.1.2 liver
-
Rattus norvegicus
-
1.1.1.2 liver
-
Sus scrofa
-
1.1.1.2 liver
-
Bos taurus
-
1.1.1.2 liver
-
Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.2 17.1
-
-
Sus scrofa

Storage Stability

EC Number Storage Stability Organism
1.1.1.2 -20°C, stable for several months if stored as an ammonium sulfate precipitate Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 (+)-camphorquinone + NADPH
-
Sus scrofa ? + NADP+
-
?
1.1.1.2 (-)-camphorquinone + NADPH relative activity 2% Sus scrofa ? + NADP+
-
?
1.1.1.2 2,3-pentanedione + NADPH + H+
-
Sus scrofa ? + NADP+
-
?
1.1.1.2 3-cyanobenzaldehyde + NADPH
-
Sus scrofa 3-cyanobenzyl alcohol + NADP+
-
?
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
Rattus norvegicus 3-pyridinemethanol + NADP+
-
r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
Sus scrofa 3-pyridinemethanol + NADP+
-
r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
Bos taurus 3-pyridinemethanol + NADP+
-
?
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
Oryctolagus cuniculus 3-pyridinemethanol + NADP+
-
r
1.1.1.2 3-pyridinemethanol + NADP+
-
Sus scrofa 3-pyridinecarboxaldehyde + NADPH
-
r
1.1.1.2 4-methylbenzyl alcohol + NADP+
-
Sus scrofa 4-methylbenzaldehyde + NADPH + H+
-
r
1.1.1.2 4-nitroacetophenone + NADPH
-
Sus scrofa 1-(4-nitrophenyl)ethanol + NADP+
-
?
1.1.1.2 4-pyridinecarboxaldehyde + NADPH
-
Rattus norvegicus 4-pyridinemethanol + NADP+
-
r
1.1.1.2 4-pyridinecarboxaldehyde + NADPH
-
Sus scrofa 4-pyridinemethanol + NADP+
-
r
1.1.1.2 4-pyridinecarboxaldehyde + NADPH
-
Oryctolagus cuniculus 4-pyridinemethanol + NADP+
-
r
1.1.1.2 acetaldehyde + NADPH + H+
-
Rattus norvegicus ethanol + NADP+
-
?
1.1.1.2 acetaldehyde + NADPH + H+
-
Sus scrofa ethanol + NADP+
-
?
1.1.1.2 adonitol + NADP+
-
Sus scrofa ? + NADPH
-
r
1.1.1.2 allactose + NADPH
-
Sus scrofa ? + NADP+
-
?
1.1.1.2 alpha-diketone + NADPH
-
Sus scrofa ? + NADP+
-
?
1.1.1.2 anisaldehyde + NADPH + H+
-
Sus scrofa anisyl alcohol + NADP+
-
r
1.1.1.2 anisyl alcohol + NADP+
-
Sus scrofa anisaldehyde + NADPH
-
r
1.1.1.2 benzaldehyde + NADPH
-
Rattus norvegicus benzyl alcohol + NADP+
-
r
1.1.1.2 benzaldehyde + NADPH
-
Bos taurus benzyl alcohol + NADP+
-
r
1.1.1.2 benzaldehyde + NADPH relative activity 4% Sus scrofa benzyl alcohol + NADP+
-
r
1.1.1.2 benzyl alcohol + NADP+
-
Sus scrofa benzaldehyde + NADPH
-
r
1.1.1.2 cyclohexanone + NADPH
-
Sus scrofa cyclohexanol + NADP+
-
?
1.1.1.2 cyclohexanone + NADPH
-
Bos taurus cyclohexanol + NADP+
-
?
1.1.1.2 D-arabinose + NADPH
-
Sus scrofa ? + NADP+
-
r
1.1.1.2 D-arabitol + NADP+
-
Sus scrofa ? + NADPH
-
r
1.1.1.2 D-erythrose + NADPH
-
Sus scrofa ? + NADP+
-
?
1.1.1.2 D-fructose + NADPH
-
Sus scrofa ? + NADP+
-
?
1.1.1.2 D-galactose + NADPH
-
Sus scrofa ? + NADP+
-
?
1.1.1.2 D-glucose + NADPH
-
Sus scrofa ? + NADP+
-
?
1.1.1.2 D-glucuronate + NADPH
-
Rattus norvegicus L-gulonate + NADP+
-
?
1.1.1.2 D-glucuronate + NADPH
-
Rattus norvegicus L-gulonate + NADP+
-
r
1.1.1.2 D-glucuronate + NADPH
-
Sus scrofa L-gulonate + NADP+
-
?
1.1.1.2 D-glucuronate + NADPH
-
Sus scrofa L-gulonate + NADP+
-
r
1.1.1.2 D-glucuronate + NADPH
-
Bos taurus L-gulonate + NADP+
-
?
1.1.1.2 D-glucuronate + NADPH
-
Bos taurus L-gulonate + NADP+
-
r
1.1.1.2 D-glucuronate + NADPH
-
Oryctolagus cuniculus L-gulonate + NADP+
-
?
1.1.1.2 D-glucuronate + NADPH
-
Oryctolagus cuniculus L-gulonate + NADP+
-
r
1.1.1.2 D-glucuronolactone + NADPH
-
Rattus norvegicus ? + NADP+
-
?
1.1.1.2 D-glucuronolactone + NADPH
-
Sus scrofa ? + NADP+
-
?
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
Rattus norvegicus glycerol + NADP+
-
r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
Sus scrofa glycerol + NADP+
-
r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
Oryctolagus cuniculus glycerol + NADP+
-
r
1.1.1.2 D-lactaldehyde + NADPH + H+
-
Sus scrofa propane-1,2-diol + NADP+
-
r
1.1.1.2 D-lactaldehyde + NADPH + H+
-
Bos taurus propane-1,2-diol + NADP+
-
r
1.1.1.2 D-ribose + NADPH
-
Sus scrofa ? + NADP+
-
?
1.1.1.2 D-sorbitol + NADP+
-
Sus scrofa ? + NADPH
-
r
1.1.1.2 D-xylose + NADPH
-
Rattus norvegicus ? + NADP+
-
?
1.1.1.2 D-xylose + NADPH
-
Sus scrofa ? + NADP+
-
?
1.1.1.2 D-xylose + NADPH
-
Bos taurus ? + NADP+
-
?
1.1.1.2 dehydro-L-ascorbate + NADPH
-
Sus scrofa ? + NADP+
-
?
1.1.1.2 diacetyl + NADPH
-
Sus scrofa ? + NADP+
-
?
1.1.1.2 erythritol + NADP+
-
Sus scrofa ? + NADPH
-
r
1.1.1.2 glycerol + NADP+
-
Rattus norvegicus DL-glyceraldehyde + NADPH + H+
-
r
1.1.1.2 glycerol + NADP+
-
Sus scrofa DL-glyceraldehyde + NADPH + H+
-
r
1.1.1.2 indolacetaldehyde + NADPH
-
Sus scrofa ? + NADP+
-
?
1.1.1.2 L-arabitol + NADP+
-
Sus scrofa ? + NADPH
-
r
1.1.1.2 L-gulonic acid + NADP+
-
Rattus norvegicus D-glucuronic acid + NADPH
-
r
1.1.1.2 L-gulonic acid + NADP+
-
Sus scrofa D-glucuronic acid + NADPH
-
r
1.1.1.2 L-gulonic acid + NADP+
-
Bos taurus D-glucuronic acid + NADPH
-
r
1.1.1.2 L-gulonic acid + NADP+
-
Oryctolagus cuniculus D-glucuronic acid + NADPH
-
r
1.1.1.2 L-gulonic acid + NADPH
-
Rattus norvegicus D-glucuronic acid + NADP+
-
r
1.1.1.2 L-gulonic acid + NADPH
-
Sus scrofa D-glucuronic acid + NADP+
-
r
1.1.1.2 L-gulonic acid + NADPH
-
Bos taurus D-glucuronic acid + NADP+
-
r
1.1.1.2 L-gulonic acid + NADPH
-
Oryctolagus cuniculus D-glucuronic acid + NADP+
-
r
1.1.1.2 L-sorbose + NADPH + H+
-
Sus scrofa ? + NADP+
-
r
1.1.1.2 L-xylose + NADPH
-
Sus scrofa ? + NADP+
-
?
1.1.1.2 m-nitrobenzaldehyde + NADPH
-
Sus scrofa m-nitrobenzylalcohol + NADP+
-
r
1.1.1.2 methylglyoxal + NADPH
-
Rattus norvegicus ? + NADP+
-
r
1.1.1.2 methylglyoxal + NADPH
-
Sus scrofa ? + NADP+
-
r
1.1.1.2 n-butanol + NADP+
-
Sus scrofa butyraldehyde + NADPH
-
r
1.1.1.2 n-butyraldehyde + NADPH relative activity 2% Sus scrofa n-butanol + NADP+
-
r
1.1.1.2 o-nitrobenzaldehyde + NADPH
-
Sus scrofa o-nitrobenzylalcohol + NADP+
-
r
1.1.1.2 p-carboxybenzaldehyde + NADPH
-
Rattus norvegicus p-carboxybenzyl alcohol + NADP+
-
r
1.1.1.2 p-carboxybenzaldehyde + NADPH
-
Sus scrofa p-carboxybenzyl alcohol + NADP+
-
r
1.1.1.2 p-carboxybenzaldehyde + NADPH
-
Bos taurus p-carboxybenzyl alcohol + NADP+
-
r
1.1.1.2 p-chlorobenzaldehyde + NADPH + H+
-
Sus scrofa p-chlorobenzyl alcohol + NADP+
-
r
1.1.1.2 p-cyanobenzaldehyde + NADPH
-
Sus scrofa p-cyanobenzyl alcohol + NADP+
-
?
1.1.1.2 p-cyanobenzaldehyde + NADPH
-
Bos taurus p-cyanobenzyl alcohol + NADP+
-
?
1.1.1.2 p-fluorobenzaldehyde + NADPH + H+
-
Sus scrofa p-fluorobenzyl alcohol + NADP+
-
?
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
Rattus norvegicus p-nitrobenzylalcohol + NADP+
-
r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
Sus scrofa p-nitrobenzylalcohol + NADP+
-
r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
Bos taurus p-nitrobenzylalcohol + NADP+
-
r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
Oryctolagus cuniculus p-nitrobenzylalcohol + NADP+
-
r
1.1.1.2 propiophenone + NADPH
-
Sus scrofa ? + NADP+
-
?
1.1.1.2 pyridoxal + NADPH
-
Sus scrofa 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol + NADP+
-
?
1.1.1.2 pyruvaldehyde + NADPH
-
Sus scrofa ? + NADP+
-
?
1.1.1.2 pyruvate + NADPH
-
Sus scrofa 2-hydroxypropanoic acid + NADP+
-
?
1.1.1.2 Tris + NADP+
-
Sus scrofa ? + NADPH
-
?

Subunits

EC Number Subunits Comment Organism
1.1.1.2 monomer
-
Rattus norvegicus
1.1.1.2 monomer
-
Bos taurus
1.1.1.2 monomer 1 * 38000, SDS-PAGE Sus scrofa

Synonyms

EC Number Synonyms Comment Organism
1.1.1.2 bovine brain aldehyde reductase
-
Bos taurus
1.1.1.2 rabbit kidney aldehyde-ketone reductase
-
Oryctolagus cuniculus
1.1.1.2 TPNH-linked aldehyde reductase
-
Sus scrofa
1.1.1.2 TPNH-specific aldehyde reductase
-
Sus scrofa
1.1.1.2 triphosphopyridine nucleotide-linked aldehyde reductase
-
Sus scrofa

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.2 0.07
-
3-Pyridinemethanol
-
Sus scrofa
1.1.1.2 0.612
-
glycerol
-
Sus scrofa
1.1.1.2 1.77
-
L-arabitol
-
Sus scrofa
1.1.1.2 5.6
-
(+)-Camphorquinone
-
Sus scrofa
1.1.1.2 11.6
-
D-glucuronate
-
Sus scrofa
1.1.1.2 13.7
-
D-Lactaldehyde
-
Sus scrofa
1.1.1.2 14.4
-
D-glyceraldehyde
-
Sus scrofa
1.1.1.2 16.6
-
4-cyanobenzaldehyde
-
Sus scrofa
1.1.1.2 19.3
-
4-Pyridinecarboxaldehyde
-
Sus scrofa
1.1.1.2 21.7
-
4-carboxybenzaldehyde
-
Sus scrofa
1.1.1.2 22
-
4-nitrobenzaldehyde
-
Sus scrofa
1.1.1.2 26.8
-
3-Pyridinecarboxaldehyde
-
Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.2 7
-
-
Bos taurus
1.1.1.2 7
-
reduction of 3-pyridinecarboxaldehyde Sus scrofa
1.1.1.2 10
-
oxidation of 3-pyridinemethanol Sus scrofa