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Literature summary extracted from

  • Tabakoff, B.; Erwin, G.
    Purification and characterization of a reduced nicotinamide adenine dinucleotide phosphate-linked aldehyde reductase from brain (1970), J. Biol. Chem., 245, 3263-3268.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.2 Amytal
-
 Bos taurus
1.1.1.2 chlorpromazine
-
 Bos taurus
1.1.1.2 chlorpromazine
-
 Rattus norvegicus
1.1.1.2 chlorpromazine-HCl
-
 Bos taurus
1.1.1.2 Phenobarbital
-
 Bos taurus
1.1.1.2 Phenobarbital
-
 Rattus norvegicus
1.1.1.2 sodium amobarbital
-
 Bos taurus
1.1.1.2 sodium phenobarbital
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.2 0.001
-
 NADPH
-
 Bos taurus
1.1.1.2 0.004
-
 p-Carboxybenzaldehyde
-
 Bos taurus
1.1.1.2 0.005
-
 p-cyanobenzaldehyde
-
 Bos taurus
1.1.1.2 0.006
-
 p-nitrobenzaldehyde
-
 Bos taurus
1.1.1.2 0.007
-
 m-chlorobenzaldehyde
-
 Bos taurus
1.1.1.2 0.016
-
 p-hydroxyphenylglycolaldehyde
-
 Bos taurus
1.1.1.2 0.017
-
 benzaldehyde
-
 Bos taurus
1.1.1.2 0.02
-
 p-tolualdehyde
-
 Bos taurus
1.1.1.2 0.027
-
 m-methoxybenzaldehyde
-
 Bos taurus
1.1.1.2 0.057
-
 p-hydroxyphenylacetaldehyde
-
 Bos taurus
1.1.1.2 0.141
-
 p-Methoxybenzaldehyde
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Bos taurus
-
 bovine
-
1.1.1.2 Oryctolagus cuniculus
-
 rabbit
-
1.1.1.2 Rattus norvegicus
-
 rat
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.2
-
 Bos taurus

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.2 a primary alcohol + NADP+ = an aldehyde + NADPH + H+ a zinc protein. Some members of this group oxidize only primary alcohols, others act also on secondary alcohols. May be identical with EC 1.1.1.19 (L-glucuronate reductase), EC 1.1.1.33 [mevaldate reductase (NADPH2)] and EC 1.1.1.55 [lactaldehyde reductase (NADPH2)]. A-specific with respect to NADH2 Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.2 brain
-
 Rattus norvegicus
-
1.1.1.2 brain
-
 Oryctolagus cuniculus
-
1.1.1.2 brain midbrain, hypothalamus and pons Bos taurus
-
1.1.1.2 intestinal mucosa
-
 Rattus norvegicus
-
1.1.1.2 kidney
-
 Rattus norvegicus
-
1.1.1.2 kidney
-
 Bos taurus
-
1.1.1.2 kidney cortex Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.2 0.3786
-
-
 Bos taurus

Storage Stability

EC Number Storage Stability Organism
1.1.1.2 0-2°C, enzyme activity retained for up to 3 months if frozen immediately after preparation, stable for several days, freezing and thawing is quite detrimental to retention of enzyme activity Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 benzaldehyde + NADPH
-
 Rattus norvegicus benzyl alcohol + NADP+
-
 r
1.1.1.2 benzaldehyde + NADPH
-
 Bos taurus benzyl alcohol + NADP+
-
 r
1.1.1.2 D-lactaldehyde + NADPH + H+
-
 Bos taurus propane-1,2-diol + NADP+
-
 r
1.1.1.2 hydroxypyruvate + ?
-
 Bos taurus ?
-
 r
1.1.1.2 iodoacetaldehyde + NADPH
-
 Bos taurus iodoethan-2-ol + NADP+
-
 r
1.1.1.2 m-chlorobenzaldehyde + NADPH + H+
-
 Bos taurus m-chlorobenzyl alcohol + NADP+
-
 r
1.1.1.2 m-methoxybenzaldehyde + NADPH + H+
-
 Bos taurus m-methoxybenzyl alcohol + NADP+
-
 r
1.1.1.2 additional information short chain aliphathic aldehydes such as actealdehyde or propionaldehyde are no substrates, benzyl-substituted ketones such as pyruvic acid are not reduced Bos taurus ?
-
 ?
1.1.1.2 p-carboxybenzaldehyde + NADPH
-
 Rattus norvegicus p-carboxybenzyl alcohol + NADP+
-
 r
1.1.1.2 p-carboxybenzaldehyde + NADPH
-
 Bos taurus p-carboxybenzyl alcohol + NADP+
-
 r
1.1.1.2 p-cyanobenzaldehyde + NADPH
-
 Bos taurus p-cyanobenzyl alcohol + NADP+
-
 r
1.1.1.2 p-hydroxyphenylacetaldehyde + NADPH + H+
-
 Rattus norvegicus p-hydroxyphenylethanol + NADP+
-
 r
1.1.1.2 p-hydroxyphenylacetaldehyde + NADPH + H+
-
 Bos taurus p-hydroxyphenylethanol + NADP+
-
 r
1.1.1.2 p-hydroxyphenylglycolaldehyde + NADPH
-
 Rattus norvegicus 4-hydroxyphenylethylalcohol + NADP+
-
 r
1.1.1.2 p-hydroxyphenylglycolaldehyde + NADPH
-
 Bos taurus 4-hydroxyphenylethylalcohol + NADP+
-
 r
1.1.1.2 p-methoxybenzaldehyde + NADPH + H+
-
 Bos taurus p-methoxybenzyl alcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Rattus norvegicus p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Oryctolagus cuniculus p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH cofactor NADPH Bos taurus p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 p-tolualdehyde + NADPH
-
 Bos taurus toluol + NADP+
-
 ?
1.1.1.2 phenylacetaldehyde + NADPH + H+
-
 Bos taurus phenylethanol + NADP+
-
 r
1.1.1.2 phenylethylamine + ?
-
 Bos taurus ?
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.2 NADPH-linked aldehyde reductase
-
 Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.2 6.7 6.8 aldehyde reductase with p-nitrobenzaldehyde and NADPH Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.2 NADPH
-
 Bos taurus