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Literature summary extracted from

  • Dehal, S.S.; Croteau, R.
    Metabolism of monoterpenes: Specificity of the dehydrogenases responsible for the biosynthesis of camphor, 3-thujone, and 3-isothujone (1987), Arch. Biochem. Biophys., 258, 287-291.
    View publication on PubMed

General Stability

EC Number General Stability Organism
1.1.1.227 stable to lyophilization Tanacetum vulgare
1.1.1.228 stable to lyophilization Salvia officinalis
1.1.1.228 stable to lyophilization Tanacetum vulgare

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.227 chloroplast
-
 Tanacetum vulgare 9507
-
1.1.1.227 soluble
-
 Tanacetum vulgare
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.198 92000
-
 gel filtration Salvia officinalis
1.1.1.227 70000
-
 gel filtration Tanacetum vulgare
1.1.1.228 70000
-
 gel filtration Tanacetum vulgare
1.1.1.228 92000
-
 gel filtration Salvia officinalis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.198 (+)-borneol + NAD+ Salvia officinalis
-
 (+)-camphor + NADH
-
 ?
1.1.1.227 (-)-borneol + NAD+ Tanacetum vulgare biosynthesis of camphor from borneol (-)-camphor + NADH + H+
-
 ?
1.1.1.228 (+)-cis-sabinol + NAD+ Salvia officinalis pathway in the biosynthesis of (-)-3-isothujone (sage) or (+)-3-thujone (tansy) (+)-sabinone + NADH
-
 ?
1.1.1.228 (+)-cis-sabinol + NAD+ Tanacetum vulgare pathway in the biosynthesis of (-)-3-isothujone (sage) or (+)-3-thujone (tansy) (+)-sabinone + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.198 Salvia officinalis
-
 sage
-
1.1.1.227 Tanacetum vulgare
-
 tansy
-
1.1.1.228 Salvia officinalis
-
 sage
-
1.1.1.228 Tanacetum vulgare
-
 tansy
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.198 partial Salvia officinalis
1.1.1.227 partial Tanacetum vulgare
1.1.1.228 partial Salvia officinalis
1.1.1.228 partial Tanacetum vulgare

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.198 leaf
-
 Salvia officinalis
-
1.1.1.198 leaf epidermis
-
 Salvia officinalis
-
1.1.1.227 leaf epidermis oil glands Tanacetum vulgare
-
1.1.1.228 leaf epidermis oil glands Salvia officinalis
-
1.1.1.228 leaf epidermis oil glands Tanacetum vulgare
-

Storage Stability

EC Number Storage Stability Organism
1.1.1.227 -40°C, lyophilized, under argon, stable for several months without deterioration Tanacetum vulgare
1.1.1.228 -40°C, lyophilized, under argon, stable for several months without deterioration Salvia officinalis
1.1.1.228 -40°C, lyophilized, under argon, stable for several months without deterioration Tanacetum vulgare

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.198 (+)-borneol + NAD+
-
 Salvia officinalis (+)-camphor + NADH
-
 ?
1.1.1.227 (-)-borneol + NAD+
-
 Tanacetum vulgare (-)-camphor + NADH + H+
-
 ?
1.1.1.227 (-)-borneol + NAD+ biosynthesis of camphor from borneol Tanacetum vulgare (-)-camphor + NADH + H+
-
 ?
1.1.1.228 (+)-cis-sabinol + NAD+
-
 Salvia officinalis (+)-sabinone + NADH
-
 ?
1.1.1.228 (+)-cis-sabinol + NAD+
-
 Tanacetum vulgare (+)-sabinone + NADH
-
 ?
1.1.1.228 (+)-cis-sabinol + NAD+ pathway in the biosynthesis of (-)-3-isothujone (sage) or (+)-3-thujone (tansy) Salvia officinalis (+)-sabinone + NADH
-
 ?
1.1.1.228 (+)-cis-sabinol + NAD+ pathway in the biosynthesis of (-)-3-isothujone (sage) or (+)-3-thujone (tansy) Tanacetum vulgare (+)-sabinone + NADH
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.198 NAD+
-
 Salvia officinalis
1.1.1.198 NADP+ 65-85% as efficient as NAD+ Salvia officinalis
1.1.1.228 additional information flavin nucleotides are ineffective Salvia officinalis
1.1.1.228 additional information flavin nucleotides are ineffective Tanacetum vulgare
1.1.1.228 NAD+
-
 Salvia officinalis
1.1.1.228 NAD+
-
 Tanacetum vulgare
1.1.1.228 NADP+ 65-85% as effective as NAD+ Salvia officinalis
1.1.1.228 NADP+ 65-85% as effective as NAD+ Tanacetum vulgare