EC Number | Application | Comment | Organism |
---|---|---|---|
1.1.1.2 | medicine | daunorubicin, a cancer chemotherapeutic agent can be reduced by aldehyde reductase | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.2 | ATP-ribose | competitive inhibition | Homo sapiens | |
1.1.1.2 | diethyldicarbonate | kidney aldehyde reductase | Homo sapiens | |
1.1.1.2 | NADP+ | competitive inhibition | Homo sapiens | |
1.1.1.19 | ATP-ribose | competitive versus NADPH | Homo sapiens | |
1.1.1.19 | menadione | competitive versus D-glucuronate | Homo sapiens | |
1.1.1.19 | pyridoxal 5'-phosphate | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.2 | D-glucuronate + NADPH | Homo sapiens | - |
L-gulonate + NADP+ | - |
r | |
1.1.1.2 | D-glyceraldehyde + NADPH + H+ | Homo sapiens | - |
glycerol + NADP+ | - |
r | |
1.1.1.2 | L-glyceraldehyde + NADPH | Homo sapiens | - |
glycerol + NADP+ | - |
r | |
1.1.1.2 | succinic semialdehyde + NADPH + H+ | Homo sapiens | - |
4-hydroxybutyrate + NADP+ | - |
r | |
1.1.1.19 | D-glucuronate + NADPH | Homo sapiens | - |
L-gulonate + NADP+ | - |
r | |
1.1.1.19 | L-gulonate + NADP+ | Homo sapiens | - |
D-glucuronate + NADPH | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.2 | Homo sapiens | - |
human | - |
1.1.1.19 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.2 | liver | - |
Homo sapiens | - |
1.1.1.19 | liver | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.2 | D-glucuronate + NADPH | - |
Homo sapiens | L-gulonate + NADP+ | - |
? | |
1.1.1.2 | D-glucuronate + NADPH | - |
Homo sapiens | L-gulonate + NADP+ | - |
r | |
1.1.1.2 | D-glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
r | |
1.1.1.2 | daunorubicin + NADPH | - |
Homo sapiens | ? + NADP+ | - |
? | |
1.1.1.2 | L-glyceraldehyde + NADPH | - |
Homo sapiens | glycerol + NADP+ | - |
r | |
1.1.1.2 | mevaldate + NADPH | - |
Homo sapiens | ? + NADP+ | - |
? | |
1.1.1.2 | succinic semialdehyde + NADPH + H+ | - |
Homo sapiens | 4-hydroxybutyrate + NADP+ | - |
r | |
1.1.1.19 | D-glucuronate + NADPH | - |
Homo sapiens | L-gulonate + NADP+ | - |
r | |
1.1.1.19 | L-gulonate + NADP+ | - |
Homo sapiens | D-glucuronate + NADPH | - |
r |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.1.1.2 | monomer | - |
Homo sapiens |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.19 | additional information | - |
additional information | 0.119 per mM * s, L-gulonate, steady state kinetic | Homo sapiens | |
1.1.1.19 | additional information | - |
additional information | 10.82 per mM * s, D-glucuronate, steady state kinetic | Homo sapiens | |
1.1.1.19 | additional information | - |
additional information | 1124 per mM * s, NADPH, steady state kinetic | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.2 | 8.5 | - |
- |
Homo sapiens |
1.1.1.19 | 8.5 | - |
substrate L-gulonate or D-glucuronate | Homo sapiens |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.19 | 7 | 10 | - |
Homo sapiens |
EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.19 | 5 | 10.5 | irreversible loss of activity below pH 5.0 and above pH 11 | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.2 | 3-acetylpyridine adenine dinucleotide phosphate | - |
Homo sapiens | |
1.1.1.19 | NADP+ | - |
Homo sapiens | |
1.1.1.19 | NADPH | - |
Homo sapiens |