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Literature summary extracted from

  • Tulsiani, D.R.P.; Touster, O.
    Resolution and partial characterization of two aldehyde reductases of mammalian liver (1977), J. Biol. Chem., 252, 2545-2550.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.19 2-mercaptoethanol
-
 Mus musculus
1.1.1.19 hydroxylamine
-
 Mus musculus
1.1.1.19 iodoacetic acid
-
 Mus musculus
1.1.1.19 NaF
-
 Mus musculus
1.1.1.19 Phenobarbital
-
 Mus musculus
1.1.1.19 Zn2+
-
 Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.19 0.036
-
 NADPH
-
 Mus musculus
1.1.1.19 0.133
-
 4-nitrobenzaldehyde
-
 Mus musculus
1.1.1.19 0.526
-
 3-Nitrobenzaldehyde
-
 Mus musculus
1.1.1.19 0.769
-
 2-nitrobenzaldehyde
-
 Mus musculus
1.1.1.19 1.05
-
 benzaldehyde
-
 Mus musculus
1.1.1.19 1.671
-
 DL-glyceraldehyde
-
 Mus musculus
1.1.1.19 9.1
-
 D-glucuronate
-
 Mus musculus
1.1.1.19 139.9
-
 D-arabinose
-
 Mus musculus
1.1.1.19 333
-
 D-glucose
-
 Mus musculus
1.1.1.19 333
-
 D-galactose
-
 Mus musculus
1.1.1.19 333
-
 D-xylose
-
 Mus musculus
1.1.1.19 333
-
 D-ribose
-
 Mus musculus
1.1.1.19 500
-
 2-deoxyglucose
-
 Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.19 33000
-
 1 * 33000, SDS-PAGE Mus musculus
1.1.1.19 35000
-
 gel filtration Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.19 D-glucuronate + NADPH Mus musculus catabolism of inositol L-gulonate + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.19 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.19
-
 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.19 liver
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.19 additional information
-
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.19 2-deoxyglucose + NADPH + H+
-
 Mus musculus ?
-
 r
1.1.1.19 2-nitrobenzaldehyde + NADPH + H+
-
 Mus musculus 2-nitrobenzyl alcohol + NADP+
-
 r
1.1.1.19 3-nitrobenzaldehyde + NADPH + H+
-
 Mus musculus 3-nitrobenzyl alcohol + NADP+
-
 r
1.1.1.19 4-nitrobenzaldehyde + NADPH 2-, and 3-isomer also reduced Mus musculus 4-nitrobenzyl alcohol + NADP+
-
 r
1.1.1.19 benzaldehyde + NADPH + H+
-
 Mus musculus benzyl alcohol + NADP+
-
 r
1.1.1.19 D-arabinose + NADPH + H+
-
 Mus musculus D-arabinitol + NADP+
-
 r
1.1.1.19 D-galactose + NADPH + H+
-
 Mus musculus D-galactitol + NADP+
-
 r
1.1.1.19 D-glucose + NADPH + H+
-
 Mus musculus D-glucitol + NADP+
-
 r
1.1.1.19 D-glucuronate + NADPH catabolism of inositol Mus musculus L-gulonate + NADP+
-
 ?
1.1.1.19 D-glyceraldehyde + NADPH + H+
-
 Mus musculus glycerol + NADP+
-
 r
1.1.1.19 D-ribose + NADPH + H+
-
 Mus musculus D-ribitol + NADP+
-
 r
1.1.1.19 D-xylose + NADPH + H+
-
 Mus musculus D-xylitol + NADP+
-
 r
1.1.1.19 DL-glyceraldehyde + NADPH + H+
-
 Mus musculus glycerol + NADP+
-
 r
1.1.1.19 additional information reduction of aldehyde greatly favored compared to oxidation of alcohol Mus musculus ?
-
 ?
1.1.1.19 pyridine-3-aldehyde + NADPH
-
 Mus musculus 3-hydroxypyridine + NADP+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.19 monomer 1 * 33000, SDS-PAGE Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.19 6 7 DL-glyceraldehyde Mus musculus
1.1.1.19 6.2 6.6 D-glucuronate Mus musculus