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Literature summary extracted from

  • Flynn, T.G.; Cromlish, J.A.; Davidson, W.S.
    Aldehyde reductase (L-hexonate: NADP dehydrogenase) from pig kidney (1982), Methods Enzymol., 89, 501-506.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.19 2,3-Butanedione
-
 Sus scrofa
1.1.1.19 diethyldicarbonate
-
 Sus scrofa
1.1.1.19 hydroxylamine
-
 Sus scrofa
1.1.1.19 iodoacetic acid
-
 Sus scrofa
1.1.1.19 NaF
-
 Sus scrofa
1.1.1.19 p-chloromercuribenzoate
-
 Sus scrofa
1.1.1.19 Phenobarbital
-
 Sus scrofa
1.1.1.19 Phenylglyoxal
-
 Sus scrofa
1.1.1.19 pyridoxal 5'-phosphate
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.19 0.009
-
 NADPH
-
 Sus scrofa
1.1.1.19 0.02
-
 NADP+ uncoupled reaction Sus scrofa
1.1.1.19 0.35
-
 4-nitrobenzaldehyde
-
 Sus scrofa
1.1.1.19 2.6
-
 Pyridine-3-aldehyde
-
 Sus scrofa
1.1.1.19 4.8
-
 D-glyceraldehyde
-
 Sus scrofa
1.1.1.19 7.3
-
 L-gulonate
-
 Sus scrofa
1.1.1.19 8.4
-
 D-glucuronate
-
 Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.19 33000
-
 SDS-PAGE, gel filtration Sus scrofa
1.1.1.19 36700
-
 1 * 36700, SDS-PAGE Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.19 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.19
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.19 kidney
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.19 5.45
-
-
 Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.19 4-nitrobenzaldehyde + NADPH
-
 Sus scrofa 4-nitrobenzyl alcohol + NADP+
-
 r
1.1.1.19 D-glyceraldehyde + NADPH + H+
-
 Sus scrofa glycerol + NADP+
-
 r
1.1.1.19 L-gulonate + NADP+
-
 Sus scrofa D-glucuronate + NADPH
-
 ?
1.1.1.19 additional information broad specificity Sus scrofa ?
-
 ?
1.1.1.19 additional information reduction of D-glyceraldehyde: pro-4R hydrogen is transferred from NADPH, i.e. A-specific, attacks re face of carbonyl group of the D-glyceraldehyde Sus scrofa ?
-
 ?
1.1.1.19 pyridine-3-aldehyde + NADPH
-
 Sus scrofa 3-hydroxypyridine + NADP+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.19 monomer 1 * 36700, SDS-PAGE Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.19 NADPH reduction of D-glyceraldehyde: pro-4R hydrogen is transferred from NADPH, i.e. A-specific, attacks re face of carbonyl group of the D-glyceraldehyde Sus scrofa