EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.185 | acetone | uncompetitive for NADH | Klebsiella aerogenes | |
1.1.1.185 | L-acetoin | probably all L(+)-alpha-hydroxycarbonyls products inhibit uncompetitively at non-saturated concentrations | Klebsiella aerogenes | |
1.1.1.185 | NAD+ | competitive inhibition for NADH | Klebsiella aerogenes |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.185 | 0.006 | - |
NADH | with ethyl pyruvate | Klebsiella aerogenes | |
1.1.1.185 | 0.0062 | - |
NADH | with 2,3-pentadione | Klebsiella aerogenes | |
1.1.1.185 | 0.0088 | - |
NADH | with diacetyl | Klebsiella aerogenes | |
1.1.1.185 | 0.0097 | - |
NADH | with methylglyoxal | Klebsiella aerogenes | |
1.1.1.185 | 1.5 | - |
diacetyl | - |
Klebsiella aerogenes | |
1.1.1.185 | 10 | - |
2,3-Pentanedione | - |
Klebsiella aerogenes | |
1.1.1.185 | 22 | - |
ethyl pyruvate | - |
Klebsiella aerogenes | |
1.1.1.185 | 90 | - |
methylglyoxal | - |
Klebsiella aerogenes |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.185 | Klebsiella aerogenes | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.1.1.185 | an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+ | ordered bi-bi-mechanism, coenzyme binds as first substrate to the enzyme | Klebsiella aerogenes |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.185 | 2,3-pentanedione + NADH | - |
Klebsiella aerogenes | L-acetylethylcarbinol + NAD+ | - |
ir | |
1.1.1.185 | diacetyl + NADH | - |
Klebsiella aerogenes | L-acetoin + NAD+ | - |
ir | |
1.1.1.185 | ethyl pyruvate + NAD(P)H | - |
Klebsiella aerogenes | ethyl lactate | - |
? | |
1.1.1.185 | methylglyoxal + NADH | - |
Klebsiella aerogenes | L-lactaldehyde | - |
ir | |
1.1.1.185 | R1-CO-CHOH-R2 + NAD(P)H | 2-hydroxycarbonyl compound e.g. glycolaldehyde, glyceraldehyde, acetoin, acetylethylcarbinol, diacetylmethylcarbinol | Klebsiella aerogenes | R1-CHOH-CHOH-R2 + NAD(P)+ | - |
r | |
1.1.1.185 | R1-CO-CHOH-R2 + NAD(P)H | much more efficient in dehydrogenase direction | Klebsiella aerogenes | R1-CHOH-CHOH-R2 + NAD(P)+ | - |
r | |
1.1.1.185 | R1-CO-CO-R2 + NAD(P)H | methylglyoxal, diacetyl, 2,3-pentanedione | Klebsiella aerogenes | R1-CO-CHOH-R2 + NAD(P)+ | - |
ir |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.185 | L-glycol dehydrogenase (NAD+) | - |
Klebsiella aerogenes |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.185 | 25 | - |
assay at | Klebsiella aerogenes |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.185 | 7 | - |
assay at | Klebsiella aerogenes |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.185 | NAD+ | - |
Klebsiella aerogenes | |
1.1.1.185 | NADH | - |
Klebsiella aerogenes |