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Literature summary extracted from

  • Van der Drift, C.; van Helvoort, P.E.M.; Vogels, G.D.
    S-ureidoglycolate dehydrogenase: Purification and properties (1971), Arch. Biochem. Biophys., 145, 465-469.
    View publication on PubMed

General Stability

EC Number General Stability Organism
1.1.1.154 incubation with 30% glycerol at 4°C for 3 h stabilizes activity Arthrobacter allantoicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.154 glycolate 18% inhibition at 17 mM Arthrobacter allantoicus
1.1.1.154 glyoxylate non-competitive inhibition, Ki: 83 mM Arthrobacter allantoicus
1.1.1.154 L-lactate 10% inhibition at 17 mM Arthrobacter allantoicus
1.1.1.154 Zn2+ 40% inhibition at 0.5 mM Arthrobacter allantoicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.154 0.1
-
 NADP+
-
 Arthrobacter allantoicus
1.1.1.154 2.16
-
 NAD+
-
 Arthrobacter allantoicus
1.1.1.154 9.1
-
 (R,S)-ureidoglycolate
-
 Arthrobacter allantoicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.154 (S)-ureidoglycolate + NAD(P)+ Arthrobacter allantoicus strong substrate specificity, involved in the degradation of allantoin to glyoxylate in microbes and lower animals oxalureate + NAD(P)H
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.154 Arthrobacter allantoicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.154 partial Arthrobacter allantoicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.154 cell culture
-
 Arthrobacter allantoicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.154 10.6
-
-
 Arthrobacter allantoicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.154 (R,S)-ureidoglycolate + NAD+
-
 Arthrobacter allantoicus oxalureate + NADH + H+
-
 r
1.1.1.154 (S)-ureidoglycolate + NAD(P)+ strong substrate specificity, involved in the degradation of allantoin to glyoxylate in microbes and lower animals Arthrobacter allantoicus oxalureate + NAD(P)H
-
 ir

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.1.1.154 30
-
 unstable above Arthrobacter allantoicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.154 8 8.4 sensitive to ionic strength Arthrobacter allantoicus

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
1.1.1.154 6
-
 decrease of activity below Arthrobacter allantoicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.154 NAD+
-
 Arthrobacter allantoicus
1.1.1.154 NADP+
-
 Arthrobacter allantoicus