Literature summary extracted from

Auerbach, G.; Herrmann, A.; Gutlich, M.; Fischer, M.; Jacob, U.; Bacher, A.; Huber, R.
The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters (1997), EMBO J., 16, 7219-7230.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.1.1.153	recombinant protein expressed in Escherichia coli	Mus musculus

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
1.1.1.153	vapour diffusion technique	Mus musculus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.153	N-acetylserotonin	-	Mus musculus
1.1.1.153	N-chloroserotonin	strong inhibitor	Mus musculus
1.1.1.153	N-methoxyacetylserotonin	strong competitive inhibitor	Mus musculus
1.1.1.153	oxaloacetate	-	Mus musculus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.153	6-(S)-lactoyl-7,8-dihydropterin + NADPH	Mus musculus	-	6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.153	Mus musculus	Q64105	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.1.1.153	recombinant protein of Escherichia coli	Mus musculus

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.153	6-(S)-lactoyl-7,8-dihydropterin + NADPH	-	Mus musculus	6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+	-	?

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Release 2023.1 (January 2023)