Literature summary extracted from

  • Smith, G.K.; Duch, D.S.; Edelstein, M.P.; Bigham, E.C.
    New inhibitors of sepiapterin reductase (1992), J. Biol. Chem., 267, 5599-5607.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.153 N-acetyldopamine potent competitive inhibitor Bos taurus
1.1.1.153 N-acetyl-L-noradrenaline weak inhibitor, N-acetyl-L-adrenaline does not bind enzyme Bos taurus
1.1.1.153 N-acetylphenethylamine weak Bos taurus
1.1.1.153 N-acetyl-p-tyramine weak, N-acetyl-m-tyramine shows strong inhibition Bos taurus
1.1.1.153 N-acetylserotonin potent competitive inhibitor Bos taurus
1.1.1.153 N-acetyltryptamine slight, N-acetyltryptophan does not bind enzyme Bos taurus
1.1.1.153 N-chloroacetyldopamine strong inhibitor Bos taurus
1.1.1.153 N-chloroacetylserotonin strong competitive inhibitor Bos taurus
1.1.1.153 N-lactoyldopamine potent inhibitor Bos taurus
1.1.1.153 N-methoxyacetylserotonin strong competitive inhibitor Bos taurus
1.1.1.153 N-pyruvoyldopamine potent inhibitor Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH Bos taurus
-
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.153 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.153
-
Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.153 adrenal gland adrenal medulla Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH
-
Bos taurus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?