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Literature summary extracted from

  • Katoh, S.; Sueoka, T.; Yamada, S.
    Direct inhibition of brain sepiapterin reductase by a catecholamine and an indoleamine (1982), Biochem. Biophys. Res. Commun., 105, 75-81.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.153 1-norepinephrine 3 mM: 30% inhibition Rattus norvegicus
1.1.1.153 catecholamine
-
 Rattus norvegicus
1.1.1.153 dopamine slight; slight inhibition Rattus norvegicus
1.1.1.153 Indoleamine
-
 Rattus norvegicus
1.1.1.153 Melatonin 3 mM, almost complete inhibition; strong inhibition Rattus norvegicus
1.1.1.153 additional information no inhibition by 1-epinephrine, phenylalanine, tyrosine, L-DOPA, L-tryptophan, L-5-hydroxy-tryptophan Rattus norvegicus
1.1.1.153 N-acetyl-serotonin complete inhibition Rattus norvegicus
1.1.1.153 N-acetylserotonin 3 mM, complete inhibition Rattus norvegicus
1.1.1.153 serotonin
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH Rattus norvegicus terminal step in the biosynthetic pathway for tetrahydrobiopterin 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
 ?
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH Rattus norvegicus Sprague-Dawley terminal step in the biosynthetic pathway for tetrahydrobiopterin 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
 ?
1.1.1.153 additional information Rattus norvegicus the enzyme might be involved in regulation of biosynthesis of catecholamines, indoleamines, and tetrahydrobiopterins ?
-
 ?
1.1.1.153 additional information Rattus norvegicus Sprague-Dawley the enzyme might be involved in regulation of biosynthesis of catecholamines, indoleamines, and tetrahydrobiopterins ?
-
 ?
1.1.1.153 sepiapterin + NADPH + H+ Rattus norvegicus
-
 7,8-dihydrobiopterin + NADP+
-
 ?
1.1.1.153 sepiapterin + NADPH + H+ Rattus norvegicus Sprague-Dawley
-
 7,8-dihydrobiopterin + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.153 Rattus norvegicus
-
 Sprague-Dawley
-
1.1.1.153 Rattus norvegicus
-
 male sprague-dawley rats
-
1.1.1.153 Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.153 brain, partially, from erythrocytes to homogeneity Rattus norvegicus
1.1.1.153 native enzyme partially from brain by ammonium sulfate fractionation and hydroxylapatite chromatography, and from erythrocytes to homogeneity by affinity chromatography and isoelectric focusing Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.153 brain
-
 Rattus norvegicus
-
1.1.1.153 brain in all parts of the brain Rattus norvegicus
-
1.1.1.153 erythrocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH
-
 Rattus norvegicus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
 ?
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH terminal step in the biosynthetic pathway for tetrahydrobiopterin Rattus norvegicus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
 ?
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH
-
 Rattus norvegicus Sprague-Dawley 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
 ?
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH terminal step in the biosynthetic pathway for tetrahydrobiopterin Rattus norvegicus Sprague-Dawley 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
 ?
1.1.1.153 additional information the enzyme might be involved in regulation of biosynthesis of catecholamines, indoleamines, and tetrahydrobiopterins Rattus norvegicus ?
-
 ?
1.1.1.153 additional information the enzyme might be involved in regulation of biosynthesis of catecholamines, indoleamines, and tetrahydrobiopterins Rattus norvegicus Sprague-Dawley ?
-
 ?
1.1.1.153 sepiapterin + NADPH + H+
-
 Rattus norvegicus 7,8-dihydrobiopterin + NADP+
-
 ?
1.1.1.153 sepiapterin + NADPH + H+
-
 Rattus norvegicus Sprague-Dawley 7,8-dihydrobiopterin + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.153 SR
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.153 25
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.153 6.4
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.153 NADPH
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.153 0.00017
-
 N-acetyl-serotonin pH 6.4, 25°C, erythrocyte enzyme Rattus norvegicus
1.1.1.153 0.0002
-
 N-acetyl-serotonin pH 6.4, 25°C, brain enzyme Rattus norvegicus
1.1.1.153 0.025
-
 Melatonin pH 6.4, 25°C, erythrocyte enzyme Rattus norvegicus
1.1.1.153 0.03
-
 Melatonin pH 6.4, 25°C, brain enzyme Rattus norvegicus
1.1.1.153 2.3
-
 serotonin pH 6.4, 25°C, brain enzyme Rattus norvegicus
1.1.1.153 2.5
-
 serotonin pH 6.4, 25°C, erythrocyte enzyme Rattus norvegicus
1.1.1.153 3.1
-
 1-norepinephrine pH 6.4, 25°C, erythrocyte enzyme Rattus norvegicus
1.1.1.153 3.4
-
 1-norepinephrine pH 6.4, 25°C, brain enzyme Rattus norvegicus