Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sueoka, T.; Katoh, S.
    Carbonyl reductase activity of sepiapterin reductase from rat erythrocytes (1985), Biochim. Biophys. Acta, 843, 193-198.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.153 6-Carboxypterin IC50 0.03 mM Rattus norvegicus
1.1.1.153 alpha-ketoglutarate slight, IC50 5 mM Rattus norvegicus
1.1.1.153 Cd2+ IC50 0.1 mM Rattus norvegicus
1.1.1.153 dicoumarol IC50 0.0006 mM Rattus norvegicus
1.1.1.153 Ethacrynic acid IC50 0.03 mM Rattus norvegicus
1.1.1.153 Hg2+ IC50 0.00009 mM Rattus norvegicus
1.1.1.153 indomethacin IC50 0.06 mM Rattus norvegicus
1.1.1.153 N-acetylserotonin IC50 0.0006 mM Rattus norvegicus
1.1.1.153 Phenobarbital slight, IC50 0.6 mM Rattus norvegicus
1.1.1.153 propionic acid IC50 0.3 mM, pH 6.4 Rattus norvegicus
1.1.1.153 pyrazole slight, IC50 1 mM Rattus norvegicus
1.1.1.153 rutin IC50 0.06 mM Rattus norvegicus
1.1.1.153 Zn2+ IC50 0.4 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.153 0.00082
-
 9,10-phenanthrene quinone
-
 Rattus norvegicus
1.1.1.153 0.0183
-
 benzil
-
 Rattus norvegicus
1.1.1.153 0.043
-
 benzylacetone
-
 Rattus norvegicus
1.1.1.153 0.118
-
 1-phenyl-1,2-propanedione cofactor NADH Rattus norvegicus
1.1.1.153 0.14
-
 propiophenone
-
 Rattus norvegicus
1.1.1.153 0.18
-
 menadione
-
 Rattus norvegicus
1.1.1.153 0.43
-
 p-nitrobenzaldehyde
-
 Rattus norvegicus
1.1.1.153 0.59
-
 Phenylglyoxal
-
 Rattus norvegicus
1.1.1.153 0.75
-
 p-quinone
-
 Rattus norvegicus
1.1.1.153 1.02
-
 diacetyl cosubstrate NADH Rattus norvegicus
1.1.1.153 1.1
-
 acetophenone
-
 Rattus norvegicus
1.1.1.153 4.4
-
 methylglyoxal
-
 Rattus norvegicus
1.1.1.153 5.19
-
 2,4-Pentanedione
-
 Rattus norvegicus
1.1.1.153 29
-
 acetoin
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH Rattus norvegicus
-
 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.153 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.153
-
 Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.153 L-erythro-7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+ enzyme also reduces carbonyl compounds of non-pteridine derivatives Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.153 erythrocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.153 1-phenyl-1,2-propanedione + NADPH
-
 Rattus norvegicus ?
-
 ?
1.1.1.153 2,4-pentanedione + NADPH
-
 Rattus norvegicus ?
-
 ?
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH
-
 Rattus norvegicus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
 ?
1.1.1.153 9,10-phenanthrenequinone + NADP+
-
 Rattus norvegicus ?
-
 ?
1.1.1.153 acetoin + NADPH
-
 Rattus norvegicus ?
-
 ?
1.1.1.153 acetophenone + NADPH
-
 Rattus norvegicus ?
-
 ?
1.1.1.153 benzil + NADPH
-
 Rattus norvegicus ?
-
 ?
1.1.1.153 benzylacetone + NADPH
-
 Rattus norvegicus ?
-
 ?
1.1.1.153 diacetyl + NADPH
-
 Rattus norvegicus ?
-
 ?
1.1.1.153 menadione + NADPH
-
 Rattus norvegicus ?
-
 ?
1.1.1.153 methylglyoxal + NADPH
-
 Rattus norvegicus ?
-
 ?
1.1.1.153 additional information enzyme is quite similar to general aldo-keto reductases, especially to carbonyl reductase Rattus norvegicus ?
-
 ?
1.1.1.153 p-nitrobenzaldehyde + NADPH
-
 Rattus norvegicus p-nitrobenzyl alcohol + NADP+
-
 ?
1.1.1.153 p-quinone + NADPH
-
 Rattus norvegicus ?
-
 ?
1.1.1.153 phenylglyoxal + NADPH
-
 Rattus norvegicus ?
-
 ?
1.1.1.153 propiophenone + NADPH
-
 Rattus norvegicus ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.153 additional information the enzyme does not contain flavin Rattus norvegicus
1.1.1.153 NADPH
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.153 0.00009
-
 IC50 0.00009 mM Rattus norvegicus Hg2+
1.1.1.153 0.0006
-
 IC50 0.0006 mM Rattus norvegicus dicoumarol
1.1.1.153 0.0006
-
 IC50 0.0006 mM Rattus norvegicus N-acetylserotonin
1.1.1.153 0.03
-
 IC50 0.03 mM Rattus norvegicus Ethacrynic acid
1.1.1.153 0.03
-
 IC50 0.03 mM Rattus norvegicus 6-Carboxypterin
1.1.1.153 0.06
-
 IC50 0.06 mM Rattus norvegicus indomethacin
1.1.1.153 0.06
-
 IC50 0.06 mM Rattus norvegicus rutin
1.1.1.153 0.1
-
 IC50 0.1 mM Rattus norvegicus Cd2+
1.1.1.153 0.3
-
 IC50 0.3 mM, pH 6.4 Rattus norvegicus propionic acid
1.1.1.153 0.4
-
 IC50 0.4 mM Rattus norvegicus Zn2+
1.1.1.153 0.6
-
 slight, IC50 0.6 mM Rattus norvegicus Phenobarbital
1.1.1.153 1
-
 slight, IC50 1 mM Rattus norvegicus pyrazole
1.1.1.153 5
-
 slight, IC50 5 mM Rattus norvegicus alpha-ketoglutarate