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Literature summary extracted from

  • Kerler, F.; Hultner, L.; Ziegler, I.; Katzenmaier, G.; Bacher, A.
    Analysis of the tetrahydrobiopterin synthesizing system during maturation of murine reticulocytes (1990), J. Cell. Physiol., 142, 268-271.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH Mus musculus terminal step in the biosynthetic pathway for tetrahydrobiopterin 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.153 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.153 bone marrow
-
 Mus musculus
-
1.1.1.153 erythrocyte
-
 Mus musculus
-
1.1.1.153 reticulocyte
-
 Mus musculus
-
1.1.1.153 spleen
-
 Mus musculus
-

Storage Stability

EC Number Storage Stability Organism
1.1.1.153 -70°C, desalted extracts, several weeks without significant loss of activity Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH
-
 Mus musculus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
 ?
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH terminal step in the biosynthetic pathway for tetrahydrobiopterin Mus musculus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.153 NADPH
-
 Mus musculus