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Literature summary extracted from

  • Werner, E.R.; Werner-Felmayer, G.; Fuchs, D.; Hausen, A.; Reibnegger, G.; Yim, J.J.; Pfleiderer, W.; Wachter, H.
    Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1, and T 24 cells. GTP-cyclohydrolase I is stimulated by interferon-gamma, and 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase are constitutively present (1990), J. Biol. Chem., 265, 3189-3192.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH Drosophila melanogaster
-
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH Homo sapiens terminal step in the biosynthetic pathway for tetrahydrobiopterin 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH Drosophila melanogaster Oregon R
-
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.153 Drosophila melanogaster
-
-
-
1.1.1.153 Drosophila melanogaster Oregon R
-
-
-
1.1.1.153 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.153
-
Drosophila melanogaster

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.153 fibroblast dermal, cell culture Homo sapiens
-
1.1.1.153 macrophage
-
Homo sapiens
-
1.1.1.153 T-24 cell
-
Homo sapiens
-
1.1.1.153 THP-1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH
-
Drosophila melanogaster 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH
-
Homo sapiens 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH terminal step in the biosynthetic pathway for tetrahydrobiopterin Homo sapiens 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH
-
Drosophila melanogaster Oregon R 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.153 NADPH
-
Homo sapiens