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Literature summary extracted from

  • Fere, J.; Naylor, E.W.
    Sepiapterin reductase in cultured human cells (1987), Biochem. Biophys. Res. Commun., 148, 1475-1481.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.153 N-acetylserotonin 0.05 mM, 90% inhibition of enzyme from stimulated mononuclear blood cells Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.153 0.006
-
 NADPH
-
 Homo sapiens
1.1.1.153 0.02
-
 sepiapterin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH Homo sapiens terminal step in the biosynthetic pathway for tetrahydrobiopterin 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.153 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.153 blood mononuclear, cell culture Homo sapiens
-
1.1.1.153 fibroblast amniotic, cell culture Homo sapiens
-
1.1.1.153 mononuclear cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH
-
 Homo sapiens 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
 ?
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH terminal step in the biosynthetic pathway for tetrahydrobiopterin Homo sapiens 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.153 NADPH
-
 Homo sapiens