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Literature summary extracted from

  • Matsubara, M.; Katoh, S.; Akino, M.; Kaufman, S.
    Sepiapterin reductase (1966), Biochim. Biophys. Acta, 122, 202-212.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.153 2,4-dinitrophenol 0.1 mM: 89% inhibition Rattus norvegicus
1.1.1.153 p-mercuribenzoate 0.1 mM, 93% inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.153 0.041
-
 sepiapterin at pH 6.0 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH Rattus norvegicus
-
 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.153 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.153 liver Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.153 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH
-
 Rattus norvegicus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.153 5.5
-
 in potassium phosphate buffer Rattus norvegicus

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
1.1.1.153 5.5
-
 unstable Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.153 NADH activity one-half that of NADPH Rattus norvegicus
1.1.1.153 NADPH
-
 Rattus norvegicus