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Literature summary extracted from

  • Monder, C.
    The forms and functions of 11beta-hydroxysteroid dehydrogenase (1993), J. Steroid Biochem. Mol. Biol., 45, 161-165.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.B40 expression in CHO cells Rattus norvegicus
1.1.1.146 expression in CHO cells Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.B40 3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid i.e. glycyrrhetinic acid; more effective for 11-dehydrogenase than for 11-oxoreductase activity Rattus norvegicus
1.1.1.146 3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid i.e. glycyrrhetinic acid; more effective for 11-dehydrogenase than for 11-oxoreductase activity Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.B40 11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ Rattus norvegicus i.e. corticosterone 21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
 ?
1.1.1.146 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH Rattus norvegicus i.e. cortisone, stable dehydrogenase activity, unstable oxidoreductase activity 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Rattus norvegicus
-
-
-
1.1.1.146 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.B40 kidney
-
 Rattus norvegicus
-
1.1.1.B40 liver
-
 Rattus norvegicus
-
1.1.1.146 kidney
-
 Rattus norvegicus
-
1.1.1.146 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ i.e. corticosterone Rattus norvegicus 21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
 ?
1.1.1.146 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH i.e. cortisone, stable dehydrogenase activity, unstable oxidoreductase activity Rattus norvegicus 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.B40 NAD+
-
 Rattus norvegicus
1.1.1.146 NADP+
-
 Rattus norvegicus