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Literature summary extracted from

  • Zhang, Y.D.; Lorenzo, B.; Reidenberg, M.M.
    Inhibition of 11beta-hydroxysteroid dehydrogenase obtained from guinea pig kidney by furosemide, naringenin and some other compounds (1994), J. Steroid Biochem. Mol. Biol., 49, 81-85.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.B40 3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid IC50: 0.254 mM; i.e. glycyrrhetinic acid Cavia porcellus
1.1.1.B40 chenodeoxycholic acid IC50: 0.513 mM Cavia porcellus
1.1.1.B40 cholic acid IC50: 3.529 mM Cavia porcellus
1.1.1.B40 Ethacrynic acid IC50: 0.452 mM Cavia porcellus
1.1.1.B40 Furosemide IC50: 0.059 mM, competitive Cavia porcellus
1.1.1.B40 naringenin IC50: 0.336 mM Cavia porcellus
1.1.1.B40 naringin IC50: 2.373 mM Cavia porcellus
1.1.1.B40 Phenylbutazone IC50: 1.358 mM Cavia porcellus
1.1.1.B40 sistosterol IC50: 1.395 mM Cavia porcellus
1.1.1.B40 stigmasterol IC50: 1.968 mM Cavia porcellus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.B40 0.008
-
 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione i.e. cortisol Cavia porcellus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.B40 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+ Cavia porcellus i.e. cortisol 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH i.e. cortisone ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Cavia porcellus
-
 guinea pig
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.B40 kidney cortex Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+ i.e. cortisol Cavia porcellus 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH i.e. cortisone ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.B40 11beta-OHSD
-
 Cavia porcellus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.B40 NADPH
-
 Cavia porcellus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.B40 0.059
-
 IC50: 0.059 mM, competitive Cavia porcellus Furosemide
1.1.1.B40 0.254
-
 IC50: 0.254 mM Cavia porcellus 3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid
1.1.1.B40 0.336
-
 IC50: 0.336 mM Cavia porcellus naringenin
1.1.1.B40 0.452
-
 IC50: 0.452 mM Cavia porcellus Ethacrynic acid
1.1.1.B40 0.513
-
 IC50: 0.513 mM Cavia porcellus chenodeoxycholic acid
1.1.1.B40 1.358
-
 IC50: 1.358 mM Cavia porcellus Phenylbutazone
1.1.1.B40 1.395
-
 IC50: 1.395 mM Cavia porcellus sistosterol
1.1.1.B40 1.968
-
 IC50: 1.968 mM Cavia porcellus stigmasterol
1.1.1.B40 2.373
-
 IC50: 2.373 mM Cavia porcellus naringin
1.1.1.B40 3.529
-
 IC50: 3.529 mM Cavia porcellus cholic acid