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Literature summary extracted from

  • Albiston, A.L.; Obeyesekere, V.R.; Smith, R.E.; Krozowski, Z.S.
    Cloning and tissue distribution of the human 11beta-hydroxysteroid dehydrogenase type 2 enzyme (1994), Mol. Cell. Endocrinol., 105, R11-R17.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.B40 expression in CHOP-C4 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.B40 3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid i.e. glycyrrhetinic acid; potent inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.B40 0.0000051
-
 11beta,21-dihydroxypregn-4-en-3,20-dione
-
 Homo sapiens
1.1.1.B40 0.000047
-
 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione i.e. cortisol Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.B40 44140
-
 x * 44140, calculation from cDNA sequence Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.B40 11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ Homo sapiens i.e. corticosterone 21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
-
 ir
1.1.1.B40 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH Homo sapiens i.e. cortisone 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+ i.e. cortisol ir
1.1.1.B40 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH Homo sapiens important role in modulating mineralocorticoid and glucocorticoid receptor occupancy by glucocorticoids 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+ i.e. cortisol ir

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.B40 colon
-
 Homo sapiens
-
1.1.1.B40 kidney highly expressed Homo sapiens
-
1.1.1.B40 ovary
-
 Homo sapiens
-
1.1.1.B40 pancreas highly expressed Homo sapiens
-
1.1.1.B40 placenta highly expressed Homo sapiens
-
1.1.1.B40 prostate gland
-
 Homo sapiens
-
1.1.1.B40 small intestine
-
 Homo sapiens
-
1.1.1.B40 spleen low levels of mRNA Homo sapiens
-
1.1.1.B40 testis low levels of mRNA Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ i.e. corticosterone Homo sapiens 21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
-
 ir
1.1.1.B40 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH i.e. cortisone Homo sapiens 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+ i.e. cortisol ir
1.1.1.B40 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH important role in modulating mineralocorticoid and glucocorticoid receptor occupancy by glucocorticoids Homo sapiens 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+ i.e. cortisol ir
1.1.1.B40 dexamethasone + NAD+ isoform 11beta-HSD2 Homo sapiens 11-dehydromethasone + NADH
-
 ir

Subunits

EC Number Subunits Comment Organism
1.1.1.B40 ? x * 44140, calculation from cDNA sequence Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.1.1.B40 11beta-HSD NAD-specific 11beta-HSD isoform type 2 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.B40 NAD+
-
 Homo sapiens