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Literature summary extracted from

  • Alfaidy, N.; Blot-Chabaud, M.; Robic, D.; Kenouch, S.; Bourbouze, R.; Bonvalet, J.P.; Farman, N.
    Characteristics and regulation of 11beta-hydroxysteroid dehydrogenase of proximal and distal nephron (1995), Biochim. Biophys. Acta, 1243, 461-468.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.B40 aldosterone sensitive Rattus norvegicus
1.1.1.146 additional information aldosterone, no effect Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.B40 1beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ Rattus norvegicus i.e. corticosterone, no reductase activity in aldosterone-sensitive collecting duct 21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
 ir
1.1.1.146 11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+ Rattus norvegicus in aldosterone-insensitive Pars Recta 21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Rattus norvegicus
-
-
-
1.1.1.146 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.B40 collecting duct aldosterone-sensitive, NAD+ specificity Rattus norvegicus
-
1.1.1.B40 kidney
-
 Rattus norvegicus
-
1.1.1.146 kidney
-
 Rattus norvegicus
-
1.1.1.146 pars recta aldosterone-insensitive, NADP+ specificity Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 1beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ i.e. corticosterone, no reductase activity in aldosterone-sensitive collecting duct Rattus norvegicus 21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
 ir
1.1.1.146 11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+ in aldosterone-insensitive Pars Recta Rattus norvegicus 21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
-
 r