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Literature summary extracted from

  • Tong, M.; Tai, H.H.
    Induction of NAD+-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells (2000), Biochem. Biophys. Res. Commun., 276, 77-81.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.141 17beta-estradiol slight activation Homo sapiens
1.1.1.141 dihydrotestosterone
-
Homo sapiens
1.1.1.141 additional information the enzyme is induced by the androgens dihydrotestosterone or testosterone and, to a lesser extent, by 17beta-estradiol and progesterone in androgen-sensitive LNCaP cells, not in hormone-independent PC3 cells, the induction of 15-PGDH is not blocked by steroid receptor antagonist RU 486 nor by antiandrogen, flutamide, but is inhibited by tyrosine kinase inhibitor, genistein, and by ERK kinase inhibitor, PD 98059, but not by protein kinase C inhibitor GF109203X, thus androgens induce 15-PGDH gene expression through an unconventional nongenomic pathway, no induction by dexamethasone, hydrocortisone, and RU 486 Homo sapiens
1.1.1.141 progesterone
-
Homo sapiens
1.1.1.141 testosterone
-
Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.141 genistein
-
Homo sapiens
1.1.1.141 PD 98059 an ERK kinase inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Homo sapiens key step in prostaglandin inactivation (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.141 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.141 LNCaP cell
-
Homo sapiens
-
1.1.1.141 prostate cancer cell
-
Homo sapiens
-
1.1.1.141 prostate gland androgen-sensitive cancer cells LNCaP and hormone-independent PC3 cells, enzyme expression is induced by steroids Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.141 additional information
-
in vivo activity in absence and presence of different androgens, overview Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or (15S)-PGE2 Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ key step in prostaglandin inactivation Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.141 15-PGDH
-
Homo sapiens
1.1.1.141 NAD+-linked 15-hydroxyprostaglandin dehydrogenase
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.141 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.141 7.5
-
assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.141 NAD+
-
Homo sapiens