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Literature summary extracted from

  • Höhl, W.; Stahl, B.; Mundkowski, R.; Hofmann, U.; Meese, C.O.; Kuhlmann, U.; Schlegel, W.
    Mass determination of 15-hydroxyprostaglandin dehydrogenase from human placenta and kinetic studies with (5Z,8E,10E,12S)-12-hydroxy-5,8,10,-heptadecatrienoic acid as substrate (1993), Eur. J. Biochem., 214, 67-73.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.141 0.00765
-
 (5Z,8E,10E,12S)-12-hydroxy-5,8,10-heptadecatrienoic acid
-
 Homo sapiens
1.1.1.141 0.01
-
 prostaglandin E2
-
 Homo sapiens
1.1.1.141 0.117
-
 NAD+
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.141 28000
-
 gel filtration, MALDI-MS Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.141 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.141
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.141 placenta
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.141 6.4
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.141 (5Z,8E,10E,12S)-12-hydroxy-5,8,10-heptadecatrienoic acid + NAD+
-
 Homo sapiens (5Z,8E,10E)-12-oxo-5,8,10-heptadecatrienoic acid + NADH
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.141 monomer 1 * 28000, SDS-PAGE Homo sapiens