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Literature summary extracted from

  • Kung-Chao, D.T.Y.; Tai, H.H.
    NAD+-dependent 15-hydroxyprostaglandin dehydrogenase from porcine kidney. II. Kinetic studies (1980), Biochim. Biophys. Acta, 614, 14-24.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.141 15-ketoprostaglandin E2
-
 Sus scrofa
1.1.1.141 adenosine-5'-diphosphoribose
-
 Sus scrofa
1.1.1.141 NAD+ product inhibition Sus scrofa
1.1.1.141 NADH
-
 Sus scrofa
1.1.1.141 prostaglandin E2 product inhibition Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.141 0.00158
-
 prostaglandin E2
-
 Sus scrofa
1.1.1.141 0.0384
-
 NAD+
-
 Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.141 Sus scrofa
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.141 (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ = (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ NAD+ is added first, followed by prostaglandin E2, 15-ketoprostaglandin is released followed by NADH Sus scrofa
a
1.1.1.141 (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ = (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ ordered bi-bi-mechanism Sus scrofa
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.141 kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
-
 Sus scrofa (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+
-
 Sus scrofa 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.141 NAD+
-
 Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.141 0.0135
-
 NADH NAD+ as the variable substrate Sus scrofa
1.1.1.141 0.02
-
 15-ketoprostaglandin E2 prostaglandin E2 as the variable substrate Sus scrofa
1.1.1.141 0.02
-
 adenosine-5'-diphosphoribose prostaglandin E2 as the variable substrate Sus scrofa
1.1.1.141 0.031
-
 15-ketoprostaglandin E2 NAD+ as the variable substrate Sus scrofa
1.1.1.141 0.225
-
 adenosine-5'-diphosphoribose NAD+ as the variable substrate Sus scrofa