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Literature summary extracted from

  • Ruckrich, M.F.; Wendel, A.; Schlegel, W.; Jackisch, R.; Jung, A.
    15-Hydroxyprostaglandin dehydrogenase from human placenta, II. Steady state kinetics and influence of prostaglandin F2alpha analogues (1975), Hoppe-Seyler's Z. Physiol. Chem., 356, 799-809.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.141 15-ketoprostaglandin E1
-
 Homo sapiens
1.1.1.141 ICI 81008
-
 Homo sapiens
1.1.1.141 NAD+
-
 Homo sapiens
1.1.1.141 NADH
-
 Homo sapiens
1.1.1.141 prostaglandin E1
-
 Homo sapiens
1.1.1.141 prostaglandin E2
-
 Homo sapiens
1.1.1.141 prostaglandin F2alpha
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.141 0.0026
-
 prostaglandin E2
-
 Homo sapiens
1.1.1.141 0.0054
-
 prostaglandin E1
-
 Homo sapiens
1.1.1.141 0.0213
-
 prostaglandin F2alpha
-
 Homo sapiens
1.1.1.141 0.0399
-
 NAD+ + prostaglandin F2alpha Homo sapiens
1.1.1.141 0.0405
-
 NAD+ + prostaglandin E2 Homo sapiens
1.1.1.141 0.0451
-
 NAD+ + prostaglandin E1 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.141 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.141 (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ = (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ ordered bi-bi-mechanism Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.141 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.141 prostaglandin E1 + NAD+
-
 Homo sapiens 15-ketoprostaglandin E1 + NADH + H+
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.141 0.0109
-
 prostaglandin E2
-
 Homo sapiens
1.1.1.141 0.0139
-
 prostaglandin E1
-
 Homo sapiens
1.1.1.141 0.015
-
 NADH substrate prostaglandin E1 Homo sapiens
1.1.1.141 0.0873
-
 prostaglandin F2alpha
-
 Homo sapiens
1.1.1.141 0.117
-
 NAD+ substrate prostaglandin E1 Homo sapiens
1.1.1.141 0.163
-
 NAD+ substrate prostaglandin F2alpha Homo sapiens
1.1.1.141 0.168
-
 NAD+ substrate prostaglandin E2 Homo sapiens
1.1.1.141 0.26
-
 15-ketoprostaglandin E1 substrate prostaglandin E1 Homo sapiens