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Literature summary extracted from

  • Jung, A.; Schlegel, W.; Jackisch, R.; Friedrich, E.J.; Wendel, A.; Ruckrich, M.F.
    15-Hydroxyprostaglandin dehydrogenase from human placenta. 1. Isolation and characterization (1975), Hoppe-Seyler's Z. Physiol. Chem., 356, 787-798.
    View publication on PubMed

General Stability

EC Number General Stability Organism
1.1.1.141 glycerol, 50%, stabilizes Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.141 ethanol slight inhibition Homo sapiens
1.1.1.141 glycerol slight inhibition Homo sapiens
1.1.1.141 NADH
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.141 32000
-
 gel filtration in the presence of mercaptoethanol Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.141 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.141
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.141 placenta
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.141 2
-
-
 Homo sapiens

Storage Stability

EC Number Storage Stability Organism
1.1.1.141 -20°C, 50% glycerol, 10 mM 2-mercaptoethanol, stable for at least 1 year Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
-
 Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+
-
 Homo sapiens 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
-
 ?
1.1.1.141 prostaglandin F2alpha + NAD+
-
 Homo sapiens 15-ketoprostaglandin F2alpha + NADH + H+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.141 9.5
-
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.141 6 10 strong increase in activity between pH 8.0 and 9.5, sharp decrease above Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.141 NAD+
-
 Homo sapiens