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Literature summary extracted from

  • Saeed, S.A.; Roy, A.C.
    Purification of 15-hydroxy prostaglandin dehydrogenase from bovine lung (1972), Biochem. Biophys. Res. Commun., 47, 96-102.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Bos taurus
-
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.141 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.141
-
Bos taurus
1.1.1.141 native enzyme from lung by ammonium sulfate fractionation and acetone precipitation Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.141 lung
-
Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.141 additional information
-
purified enzyme Bos taurus
1.1.1.141 70
-
enzyme from lung Bos taurus

Storage Stability

EC Number Storage Stability Organism
1.1.1.141 -20°C Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
-
Bos taurus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or (15S)-PGE2 Bos taurus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
1.1.1.141 11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+
-
Bos taurus 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
-
?
1.1.1.141 additional information the enzyme catalyzes specifically the oxidation of the (15S)-hydroxy group of all natural prostaglandins except the B and 19-hydroxylated types Bos taurus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.141 15-hydroxy prostaglandin dehydrogenase
-
Bos taurus
1.1.1.141 NAD+-15-hydroxy prostanoate oxidoreductase
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Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.141 8.7
-
assay at Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.141 NAD+
-
Bos taurus