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Literature summary extracted from

  • Lindstad, R.I.; Hermansen, L.F.; McKinley-McKee, J.S.
    Inhibition and activation studies on sheep liver sorbitol dehydrogenase (1994), Eur. J. Biochem., 221, 847-854.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.14 (R)-(-)-2-octanol at pH 9.9 Ovis aries
1.1.1.14 (S)-(+)-2-octanol at pH 9.9 Ovis aries
1.1.1.14 1-Hexanol
-
 Ovis aries
1.1.1.14 1-Octanol
-
 Ovis aries
1.1.1.14 2,2,2-tribromoethanol
-
 Ovis aries
1.1.1.14 2,2,2-trichloroethanol
-
 Ovis aries
1.1.1.14 2,2,2-Trifluoroethanol
-
 Ovis aries
1.1.1.14 2-monobromoethanol
-
 Ovis aries
1.1.1.14 2-monochloroethanol
-
 Ovis aries
1.1.1.14 2-monofluoroethanol
-
 Ovis aries
1.1.1.14 NaBr
-
 Ovis aries
1.1.1.14 NaCl
-
 Ovis aries
1.1.1.14 NaI
-
 Ovis aries
1.1.1.14 SDS
-
 Ovis aries
1.1.1.14 sodium taurodeoxycholate
-
 Ovis aries

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.14 (2S)-1-(3-thio-2-methylpropionyl)-L-proline
-
 Ovis aries
1.1.1.14 1,10-phenanthroline
-
 Ovis aries
1.1.1.14 1,2,3,4,5,6-cyclohexanehexolphosphoric acid at pH 9.9 Ovis aries
1.1.1.14 1,2-dithioethane
-
 Ovis aries
1.1.1.14 1,7-phenanthroline
-
 Ovis aries
1.1.1.14 1-thiobutane
-
 Ovis aries
1.1.1.14 1-thioglycol
-
 Ovis aries
1.1.1.14 1-thiosorbitol
-
 Ovis aries
1.1.1.14 2,2'-dipyridyl
-
 Ovis aries
1.1.1.14 2,3-Dithiopropanol
-
 Ovis aries
1.1.1.14 2-hydroxybenzoic acid at pH 9.9 Ovis aries
1.1.1.14 2-mercaptoethanol
-
 Ovis aries
1.1.1.14 2-methypropanoic acid amide at pH 9.9 Ovis aries
1.1.1.14 2-propylpentanoic acid at pH 9.9 Ovis aries
1.1.1.14 2-thiobutane
-
 Ovis aries
1.1.1.14 3,4-dihydroxyphenyl-1-hydroxyacetic acid at pH 7.4 Ovis aries
1.1.1.14 3,4-dihydroxyphenyl-ethanediol at pH 7.4 Ovis aries
1.1.1.14 3-hydroxy-4-methoxy-phenyl-1-hydroxy-acetic acid at pH 7.4 Ovis aries
1.1.1.14 4,4'-dipyridyl
-
 Ovis aries
1.1.1.14 4-hydroxy-3-methoxy-phenyl-1-hydroxy-acetic acid at pH 7.4 Ovis aries
1.1.1.14 4-hydroxy-3-methoxy-phenylacetic acid at pH 7.4 Ovis aries
1.1.1.14 4-hydroxy-3-methoxy-phenylethanediol at pH 7.4 Ovis aries
1.1.1.14 4-hydroxy-3-methoxy-phenylethyl alcohol at pH 7.4 Ovis aries
1.1.1.14 8-hydroxyquinoline
-
 Ovis aries
1.1.1.14 acetic acid amide at pH 9.9 Ovis aries
1.1.1.14 Alrestatin
-
 Ovis aries
1.1.1.14 Berberine
-
 Ovis aries
1.1.1.14 bis-diethylthiocarbamoyldisulfide
-
 Ovis aries
1.1.1.14 butanedioic acid at pH 9.9 Ovis aries
1.1.1.14 Cibacron Blue 3G-A
-
 Ovis aries
1.1.1.14 cyanamide at pH 9.9 Ovis aries
1.1.1.14 cysteamine significant only at pH 9.9 Ovis aries
1.1.1.14 cysteine
-
 Ovis aries
1.1.1.14 Decanoic acid at pH 9.9 Ovis aries
1.1.1.14 Diethylthiocarbamate at pH 9.9 Ovis aries
1.1.1.14 dithiothreitol
-
 Ovis aries
1.1.1.14 DL-2-thiovaline
-
 Ovis aries
1.1.1.14 Eriochrome Black T
-
 Ovis aries
1.1.1.14 ethanedioic acid at pH 9.9 Ovis aries
1.1.1.14 ICI 171071
-
 Ovis aries
1.1.1.14 ICI 222155
-
 Ovis aries
1.1.1.14 imidazole
-
 Ovis aries
1.1.1.14 Isonicotinic acid hydrazide
-
 Ovis aries
1.1.1.14 ponalrestat
-
 Ovis aries
1.1.1.14 propanedioic acid at pH 9.9 Ovis aries
1.1.1.14 pyrazole
-
 Ovis aries
1.1.1.14 quercetin at pH 7.4 Ovis aries
1.1.1.14 thioacetate at pH 9.9 Ovis aries
1.1.1.14 thiocyanate at pH 9.9 Ovis aries
1.1.1.14 Thiourea at pH 9.9 Ovis aries
1.1.1.14 Tolrestat
-
 Ovis aries
1.1.1.14 Urea at pH 9.9 Ovis aries

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.14 Ovis aries
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.14 liver
-
 Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.14 D-sorbitol + NAD+
-
 Ovis aries D-fructose + NADH + H+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.14 NAD+
-
 Ovis aries
1.1.1.14 NADH
-
 Ovis aries