Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Boutelje, J.; Hult, K.; Gatenbeck, S.
    Mannitol dehydrogenase from industrial waste mycelium of Penicillium chrysogenum. Purification, properties and possible use in cofactor regenerating systems in vitro (1983), Eur. J. Appl. Microbiol. Biotechnol., 17, 7-12.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.138 Cd2+ 65% inhibition at 0.002 mM Penicillium chrysogenum
1.1.1.138 Cu2+ complete inhibition at 1 mM Penicillium chrysogenum
1.1.1.138 Fe2+ 86% inhibition at 1 mM Penicillium chrysogenum
1.1.1.138 Hg2+ complete inhibition at 1 mM Penicillium chrysogenum
1.1.1.138 Mn2+ 11% inhibition at 1 mM Penicillium chrysogenum
1.1.1.138 NADP+ Ki: 0.021 mM Penicillium chrysogenum
1.1.1.138 Sn2+ 29% inhibition at 1 mM Penicillium chrysogenum
1.1.1.138 Zn2+ 30% inhibition at 0.02 mM Penicillium chrysogenum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.138 0.014
-
NADP+
-
Penicillium chrysogenum
1.1.1.138 0.76
-
D-mannitol
-
Penicillium chrysogenum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.138 Mg2+ 35% activation at 10 mM Penicillium chrysogenum

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.138 40000
-
4 * 40000, SDS-PAGE Penicillium chrysogenum
1.1.1.138 160000
-
gel filtration Penicillium chrysogenum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.138 D-mannitol + NADP+ Penicillium chrysogenum
-
D-fructose + NADPH + H+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.138 Penicillium chrysogenum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.138 to homogeneity, chromatography techniques Penicillium chrysogenum

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.138 mycelium
-
Penicillium chrysogenum
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.138 18.1
-
-
Penicillium chrysogenum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.138 D-mannitol + NADP+
-
Penicillium chrysogenum D-fructose + NADPH + H+
-
?
1.1.1.138 L-arabinitol + NADP+ 5% of the activity compared to D-mannitol Penicillium chrysogenum L-xylulose + NADPH + H+
-
?
1.1.1.138 L-sorbitol + NADP+ 4% of the activity compared to D-mannitol Penicillium chrysogenum L-sorbose + NADPH
-
r

Subunits

EC Number Subunits Comment Organism
1.1.1.138 tetramer 4 * 40000, SDS-PAGE Penicillium chrysogenum

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.1.1.138 30
-
50 mM MOPS-KOH buffer, pH 6.0, stable for 5 days Penicillium chrysogenum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.138 7.3
-
50 mM MOPS-KOH buffer Penicillium chrysogenum

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
1.1.1.138 6
-
50 mM MOPS-KOH buffer, after an initial loss of 25% of activity stable for 5 days at 30°C Penicillium chrysogenum

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.138 NADP+ cannot be replaced by NAD+ Penicillium chrysogenum