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Literature summary extracted from

  • Mitsuya, Y.; Kawai, S.; Kobayashi, H.
    Influence of macrolides on guanosine diphospho-D-mannose dehydrogenase activity in Pseudomonas biofilm (2000), J. Infect. Chemother., 6, 45-50.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.132 erythromycin potent dose-dependent inhibitory effect, inhibition of biofilm formation, PT-1578 Pseudomonas aeruginosa
1.1.1.132 midecamycin weaker inhibition, no biofilm destruction, PT-1578 Pseudomonas aeruginosa

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.132 Pseudomonas aeruginosa
-
 mucoid clinical isolate PT-1578 and non-mucoid PAO1, very low activity of PAO1 regardless whether using nutrient-rich or poor medium, low activity with PT-1578 on enriched, increased on nutritionally poor medium
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.132 GDP-mannose + NAD+ + H2O
-
 Pseudomonas aeruginosa GDP-mannuronate + NADH
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.132 NAD+
-
 Pseudomonas aeruginosa