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Literature summary extracted from

  • Tavares, I.M.; Leitao, J.H.; Fialho, A.M.; Sa-Correia, I.
    Pattern of changes in the activity of enzymes of GDP-D-mannuronic acid synthesis and in the level of transcription of algA, algC and algD genes accompanying the loss and emergence of mucoidy in Pseudomonas aeruginosa (1999), Res. Microbiol., 150, 105-116.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.132 Pseudomonas aeruginosa
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 mucoid strains of cystic fibrosis patients 8821, its high-alginate-producing spontaneously variant 8821M, IST23, IST27 and IST30, mucoid strains derived from the spontaneous nonmucoid strains during prolonged incubation under nutrient limitation in acetamide broth (Nm), rich in PolyP, no activity in spontaneous swiched nonmucoid variants (N) of initial isolated mucoid strains
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Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.132 0.002 0.015 mucoid forms, activity correlated with alginate production and level of transcription of algD gene Pseudomonas aeruginosa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.132 GDP-mannose + NAD+ + H2O
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 Pseudomonas aeruginosa GDP-mannuronate + NADH
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 ir

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.132 NAD+
-
 Pseudomonas aeruginosa