EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.101 | Clofibrate | activation | Mus musculus |
EC Number | General Stability | Organism |
---|---|---|
1.1.1.101 | NADPH enhances thermal stability | Cavia porcellus |
1.1.1.101 | stable toward high concentrations of N-ethylmaleimide or DTNB | Cavia porcellus |
1.1.1.101 | thiols stabilize solubilized enzyme | Cavia porcellus |
1.1.1.101 | Triton X-100, stable to solubilization in the presence of high salt concentrations | Cavia porcellus |
1.1.1.101 | trypsin inactivates | Cavia porcellus |
1.1.1.101 | trypsin inactivates | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.101 | alkyldihydroxyacetone phosphate | at high concentrations | Cavia porcellus | |
1.1.1.101 | additional information | DTNB and thiols; stable to N-ethylmaleimide | Cavia porcellus | |
1.1.1.101 | NADP+ | competitive to NADPH | Cavia porcellus | |
1.1.1.101 | palmitoyl-CoA | - |
Cavia porcellus | |
1.1.1.101 | Trypsin | inactivation | Cavia porcellus | |
1.1.1.101 | Trypsin | inactivation | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.101 | 0.01 | - |
NADPH | - |
Rattus norvegicus | |
1.1.1.101 | 0.01 | - |
NADPH | Km-value below: hexadecyldihydroxyacetone phosphate + NADPH, microsomal enzyme | Cavia porcellus | |
1.1.1.101 | 0.02 | - |
NADPH | cosubstrate palmitoyldihydroxyacetone phosphate, microsomal enzyme | Cavia porcellus | |
1.1.1.101 | 0.02 | - |
NADPH | ,cosubstrate hexadecyldihydroxyacetone phosphate, microsomal enzyme | Cavia porcellus | |
1.1.1.101 | 0.05 | - |
NADPH | hexadecyldihydroxyacetone phosphate, peroxisomal enzyme | Cavia porcellus | |
1.1.1.101 | 0.06 | - |
NADPH | cosubstrate palmitoyldihydroxyacetone phosphate, peroxisomal enzyme | Cavia porcellus | |
1.1.1.101 | 0.07 | - |
NADPH | in presence of NADP+, microsomal enzyme | Cavia porcellus | |
1.1.1.101 | 0.08 | - |
NADH | cosubstrate hexadecyldihydroxyacetone phosphate, microsomal enzyme, NADPH, cosubstrate hexadecyldihydroxyacetone phosphate, peroxisomal enzyme | Cavia porcellus | |
1.1.1.101 | 0.08 | - |
NADH | enzyme isolated from microsome | Cavia porcellus | |
1.1.1.101 | 0.13 | - |
NADPH | in presence of NADP+, peroxisomal enzyme | Cavia porcellus | |
1.1.1.101 | 0.8 | - |
NADH | cosubstrate hexadecyldihydroxyacetone phosphate, peroxisomal enzyme | Cavia porcellus | |
1.1.1.101 | 0.8 | - |
NADH | enzyme isolated from peroxisome | Cavia porcellus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.101 | acyldihydroxyacetone phosphate + NADPH | Cavia porcellus | reaction in non-ether lipids biosynthesis | 1-acyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
1.1.1.101 | acyldihydroxyacetone phosphate + NADPH | Mus musculus | reaction in non-ether lipids biosynthesis | 1-acyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
1.1.1.101 | acyldihydroxyacetone phosphate + NADPH | Rattus norvegicus | reaction in non-ether lipids biosynthesis | 1-acyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
1.1.1.101 | alkyldihydroxyacetone phosphate + NADPH + H+ | Cavia porcellus | reaction in ether lipids biosynthesis | 1-alkyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
1.1.1.101 | alkyldihydroxyacetone phosphate + NADPH + H+ | Mus musculus | reaction in ether lipids biosynthesis | 1-alkyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
1.1.1.101 | alkyldihydroxyacetone phosphate + NADPH + H+ | Rattus norvegicus | reaction in ether lipids biosynthesis | 1-alkyl-sn-glycerol 3-phosphate + NADP+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.101 | Cavia porcellus | - |
- |
- |
1.1.1.101 | Mus musculus | - |
- |
- |
1.1.1.101 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.101 | partial, solubilization | Cavia porcellus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.101 | liver | - |
Cavia porcellus | - |
1.1.1.101 | liver | - |
Mus musculus | - |
1.1.1.101 | liver | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.1.1.101 | 0.0186 | - |
light mitochondrial fraction | Mus musculus |
1.1.1.101 | 0.0296 | - |
light mitochondrial fraction, clofibrate-fed animals | Mus musculus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.101 | acyldihydroxyacetone phosphate + NADPH | - |
Cavia porcellus | 1-acyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
1.1.1.101 | acyldihydroxyacetone phosphate + NADPH | - |
Mus musculus | 1-acyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
1.1.1.101 | acyldihydroxyacetone phosphate + NADPH | - |
Rattus norvegicus | 1-acyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
1.1.1.101 | acyldihydroxyacetone phosphate + NADPH | reaction in non-ether lipids biosynthesis | Cavia porcellus | 1-acyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
1.1.1.101 | acyldihydroxyacetone phosphate + NADPH | reaction in non-ether lipids biosynthesis | Mus musculus | 1-acyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
1.1.1.101 | acyldihydroxyacetone phosphate + NADPH | reaction in non-ether lipids biosynthesis | Rattus norvegicus | 1-acyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
1.1.1.101 | alkyldihydroxyacetone phosphate + NADPH + H+ | - |
Mus musculus | 1-alkyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
1.1.1.101 | alkyldihydroxyacetone phosphate + NADPH + H+ | ether analog of acyl dihydroxyacetone phosphate | Cavia porcellus | 1-alkyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
1.1.1.101 | alkyldihydroxyacetone phosphate + NADPH + H+ | ether analog of acyl dihydroxyacetone phosphate | Rattus norvegicus | 1-alkyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
1.1.1.101 | alkyldihydroxyacetone phosphate + NADPH + H+ | reaction in ether lipids biosynthesis | Cavia porcellus | 1-alkyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
1.1.1.101 | alkyldihydroxyacetone phosphate + NADPH + H+ | reaction in ether lipids biosynthesis | Mus musculus | 1-alkyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
1.1.1.101 | alkyldihydroxyacetone phosphate + NADPH + H+ | reaction in ether lipids biosynthesis | Rattus norvegicus | 1-alkyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
1.1.1.101 | hexadecyl dihydroxyacetone phosphate + NADH + H+ | - |
Cavia porcellus | 1-hexadecyl-sn-glycerol 3-phosphate + NAD+ | - |
r | |
1.1.1.101 | hexadecyldihydroxyacetone phosphate + NADPH | - |
Cavia porcellus | 1-hexadecyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
1.1.1.101 | hexadecyldihydroxyacetone phosphate + NADPH | - |
Rattus norvegicus | 1-hexadecyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
1.1.1.101 | palmitoylglycerone phosphate + NADPH | i.e. palmitoyldihydroxyacetone phosphate | Cavia porcellus | 1-palmitoylglycerol 3-phosphate + NADP+ | - |
? | |
1.1.1.101 | palmitoylglycerone phosphate + NADPH | i.e. palmitoyldihydroxyacetone phosphate | Rattus norvegicus | 1-palmitoylglycerol 3-phosphate + NADP+ | - |
? |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.101 | 55 | - |
10% loss of activity after 15 min, NADPH enhances thermal stability | Cavia porcellus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.101 | 6.5 | - |
- |
Cavia porcellus |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.101 | 5.5 | 8.2 | about half-maximal activity at pH 5.5 and 8.2 | Cavia porcellus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.101 | NADH | - |
Cavia porcellus | |
1.1.1.101 | NADH | - |
Rattus norvegicus | |
1.1.1.101 | NADPH | hydrogen from B-side of nicotinamide ring is transferred to reduce keto substrates | Cavia porcellus | |
1.1.1.101 | NADPH | hydrogen from B-side of nicotinamide ring is transferred to reduce keto substrates | Mus musculus | |
1.1.1.101 | NADPH | hydrogen from B-side of nicotinamide ring is transferred to reduce keto substrates | Rattus norvegicus |