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Literature summary extracted from
- Organ-specific human alcohol dehydrogenase: isolation and characterization of isozymes from testis (1986), Biochem. Biophys. Res. Commun., 134, 1056-1063.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.1 | 4-Methylpyrazole | class III enzyme is completely insensitive to inhibition | Homo sapiens |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.1 | 0.056 | - |
12-Hydroxydodecanoic acid | - |
Homo sapiens | |
| 1.1.1.1 | 0.55 | - |
1-Octanol | - |
Homo sapiens | |
| 1.1.1.1 | 27 | - |
1-Pentanol | - |
Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.1 | 40000 | - |
x * 40000, SDS-PAGE | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.1 | Homo sapiens | - |
class III isoenzyme | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.1 | testis | the class III enzyme contributes by far the bulk of the total alcohol dehydrogenase activity | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.1 | 12-hydroxydodecanoate + NAD+ | - |
Homo sapiens | 12-oxododecanoic acid + NADH | - |
? | |
| 1.1.1.1 | ethanol + NAD+ | no oxidation with class III enzyme | Homo sapiens | acetaldehyde + NADH | - |
? | |
| 1.1.1.1 | methanol + NAD+ | no activity with class III enzyme | Homo sapiens | formaldehyde + NADH + H+ | - |
? | |
| 1.1.1.1 | octan-1-ol + NAD+ | - |
Homo sapiens | n-octanal + NADH | - |
? | |
| 1.1.1.1 | pentanol + NAD+ | - |
Homo sapiens | n-pentanal + NADH | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.1.1.1 | ? | x * 40000, SDS-PAGE | Homo sapiens |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.1 | 0.183 | - |
1-Pentanol | - |
Homo sapiens | |
| 1.1.1.1 | 0.333 | - |
12-Hydroxydodecanoic acid | - |
Homo sapiens | |
| 1.1.1.1 | 2.83 | - |
1-Octanol | - |
Homo sapiens | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.1 | NAD+ | - |
Homo sapiens | |
| 1.1.1.1 | NADH | - |
Homo sapiens | |
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