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Literature summary extracted from
- Comparative kinetics of human and rat liver alcohol dehydrogenase (1983), Biochem. Soc. Trans., 11, 729-730.
No PubMed abstract available
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.1 | pyrazole | 0.05 mM, 50% inhibition | Homo sapiens |  |
| 1.1.1.1 | pyrazole | 0.05 mM, complete inhibition | Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.1 | 0.8 | - |
ethanol | - |
Rattus norvegicus | |
| 1.1.1.1 | 1.8 | - |
ethanol | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.1 | ethanol + NAD+ | Homo sapiens | enzyme is responsible for the major ethanol oxidation capacity in the body. The products acetaldehyde and NADH are responsible for the most of the toxic effects and metabolic disturbances produced by ethanol ingestion | acetaldehyde + NADH | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.1 | Homo sapiens | - |
- |
- |
| 1.1.1.1 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.1 | liver | - |
Homo sapiens | - |
| 1.1.1.1 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.1 | ethanol + NAD+ | - |
Homo sapiens | acetaldehyde + NADH | - |
? | |
| 1.1.1.1 | ethanol + NAD+ | - |
Rattus norvegicus | acetaldehyde + NADH | - |
? | |
| 1.1.1.1 | ethanol + NAD+ | enzyme is responsible for the major ethanol oxidation capacity in the body. The products acetaldehyde and NADH are responsible for the most of the toxic effects and metabolic disturbances produced by ethanol ingestion | Homo sapiens | acetaldehyde + NADH | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.1 | 10.5 | - |
- |
Homo sapiens |
| 1.1.1.1 | 10.5 | - |
- |
Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.1 | NAD+ | - |
Homo sapiens | |
| 1.1.1.1 | NAD+ | - |
Rattus norvegicus | |
| 1.1.1.1 | NADH | - |
Homo sapiens | |
| 1.1.1.1 | NADH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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