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Literature summary extracted from
- A microsomal ecdysone-binding cytochrome P-450 from the insect Locusta migratoria purified by sequential use of type-II and type-I ligands (2001), Biol. Chem., 382, 1541-1549.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.99.22 | cloned CYP6H1 cDNA is probably identical with purified enzyme | Locusta migratoria migratorioides |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.99.22 | microsome | - |
Locusta migratoria migratorioides | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.99.22 | 60000 | - |
? * 60000, SDS-PAGE | Locusta migratoria migratorioides |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.99.22 | ecdysone + NADPH + O2 | Locusta migratoria migratorioides | - |
20-hydroxyecdysone + NADP+ + H2O | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.99.22 | Locusta migratoria migratorioides | - |
migration locust | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.14.99.22 | solubilization of the enzyme from microsomes with detergent Synperonic NP10 | Locusta migratoria migratorioides |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.99.22 | malpighian tubule | last instar larvae | Locusta migratoria migratorioides | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.99.22 | alpha-ecdysone + NADPH + O2 | - |
Locusta migratoria migratorioides | 20-hydroxyecdysone + NADP+ + H2O | - |
? | |
| 1.14.99.22 | ecdysone + NADPH + O2 | - |
Locusta migratoria migratorioides | 20-hydroxyecdysone + NADP+ + H2O | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.14.99.22 | ? | ? * 60000, SDS-PAGE | Locusta migratoria migratorioides |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.99.22 | cytochrome P450 | essential | Locusta migratoria migratorioides | |
| 1.14.99.22 | NADPH | - |
Locusta migratoria migratorioides | |
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Release 2023.1 (January 2023)
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