Literature summary extracted from

Denner, K.; Vogel, R.; Schmalix, W.; Doehmer, J.; Bernhardt, R.
Cloning and stable expression of the human mitochondrial cytochrome P45011B1 cDNA in V79 Chinese hamster cells and their application for testing of potential inhibitors (1995), Pharmacogenetics, 5, 89-96.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.14.15.4	full-length P45011B1 cDNA cloned into and expressed in lung fibroblast derived V79 Chinese hamster cells	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.14.15.4	clotrimazole	azole derivative, antimycotic drug, strong dose-dependent inhibition	Homo sapiens
1.14.15.4	ketoconazole	azole derivative, antimycotic drug, strong dose-dependent inhibition	Homo sapiens
1.14.15.4	Metyrapone	diagnostic inhibitor, strong inhibition, 0.02 mM complete inhibition	Homo sapiens
1.14.15.4	miconazole	azole derivative, antimycotic drug, strong dose-dependent inhibition	Homo sapiens
1.14.15.4	spironolactone	diuretic and antihypertensive drug, competitive aldosterone antagonist, slight inhibition	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.14.15.4	mitochondrion	-	Homo sapiens	5739	-

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
1.14.15.4	55555	-	x * 55555, calculated from full-length cDNA of 1.5 kb	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.15.4	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.15.4	adrenal gland	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.15.4	11-deoxycorticosterone + reduced adrenal ferredoxin + O2	11beta-hydroxylation	Homo sapiens	corticosterone + oxidized adrenal ferredoxin + H2O	-	?
1.14.15.4	11-deoxycortisol + reduced adrenal ferredoxin + O2	11beta-hydroxylation	Homo sapiens	cortisol + oxidized adrenal ferredoxin + H2O	-	?

Subunits

EC Number	Subunits	Comment	Organism
1.14.15.4	?	x * 55555, calculated from full-length cDNA of 1.5 kb	Homo sapiens

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
1.14.15.4	37	-	-	Homo sapiens

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
1.14.15.4	7.4	-	-	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.14.15.4	NADPH	adrenodoxin and adrenodoxin reductase required in cell line homogenates, in living cells in absence of cofactors	Homo sapiens

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Release 2023.1 (January 2023)