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Literature summary extracted from
- Investigation of the component reactions of oxidative sterol demethylation. Study of the aerobic and anaerobic processes (1967), Biochemistry, 6, 2673-2678.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.18.9 | microsome | - |
Rattus norvegicus | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.18.9 | Rattus norvegicus | - |
male, adult | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.18.9 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.18.9 | 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + a ferrocytochrome + O2 | - |
Rattus norvegicus | 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + a ferricytochrome + CO2 | products of two step hydroxylase and demethylase activity, labile intermediate 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol and 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol | ? |  |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.18.9 | NADH | - |
Rattus norvegicus | |
| 1.14.18.9 | NADPH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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