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Literature summary extracted from

  • Van Nistelrooy, J.G.M.; Van den Brink, J.M.; Van Kan, J.A.L.; Van Gorcom, R.F.M.; de Waard, M.A.
    Isolation and molecular characterisation of the gene encoding eburicol 14alpha-demethylase (CYP51) from Penicillium italicum (1996), Mol. Gen. Genet., 250, 725-733.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.154 cDNA, introduced into Aspergillus niger by transformation Penicillium italicum

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.154 fungicides
-
 Penicillium italicum

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.14.154 57300
-
 amino acid analysis Penicillium italicum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.154 eburicol + [reduced NADPH-hemoprotein reductase] + O2 Penicillium italicum
-
 ? + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.154 Candida albicans
-
-
-
1.14.14.154 Candida tropicalis
-
-
-
1.14.14.154 Penicillium italicum
-
 filamentous fungal plant pathogen
-
1.14.14.154 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.154 eburicol + O2 + [reduced NADPH-hemoprotein reductase] + O2
-
 Penicillium italicum 2-(3-hydroxy-4,4,10,13-tetramethyl-2,3,4,5,6,7,10,11,12,13,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-methyl-5-methylene-heptanoic acid + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.154 eburicol + [reduced NADPH-hemoprotein reductase] + O2
-
 Penicillium italicum ? + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2 lanosta-8,24-dien-3beta-ol Saccharomyces cerevisiae 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2 lanosta-8,24-dien-3beta-ol Candida albicans 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2 lanosta-8,24-dien-3beta-ol Candida tropicalis 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2 4,4,14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol Saccharomyces cerevisiae 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2 4,4,14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol Candida albicans 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2 4,4,14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol Candida tropicalis 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.154 cytochrome P450
-
 Saccharomyces cerevisiae
1.14.14.154 cytochrome P450
-
 Candida albicans
1.14.14.154 cytochrome P450
-
 Candida tropicalis
1.14.14.154 cytochrome P450
-
 Penicillium italicum
1.14.14.154 heme heme-thiolate enzyme Saccharomyces cerevisiae
1.14.14.154 heme heme-thiolate enzyme Candida albicans
1.14.14.154 heme heme-thiolate enzyme Candida tropicalis
1.14.14.154 heme heme-thiolate enzyme Penicillium italicum