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Literature summary extracted from

  • Aoyama, Y.; Horiuchi, T.; Yoshida, Y.
    Lanosterol 14-demethylase activity expressed in rat brain microsomes (1996), J. Biochem., 120, 982-986.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.14.154 cytosolic carrier required for maximum activity Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.154 CO high partial pressure of CO, ratio CO:O2 of 95:5 causes 48% inhibition Rattus norvegicus
1.14.14.154 ketoconazole potent inhibitor, 0.015 mM: complete inhibition Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.154 membrane
-
Rattus norvegicus 16020
-
1.14.14.154 microsome
-
Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2 Rattus norvegicus lanosta-8,24-dien-3beta-ol 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2 Rattus norvegicus 4,4,14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
1.14.14.154 additional information Rattus norvegicus brain microsomes, existence of sterol biosynthetic pathway in brain, cholesterol is synthesized de novo in brain ?
-
?
1.14.14.154 additional information Rattus norvegicus lanosterol 14-demethylation is situated at the root of sterol-biosynthetic branch of mevalonic acid pathway ?
-
?
1.14.14.154 additional information Rattus norvegicus enzyme of sterol biosynthetic pathway ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.154 Rattus norvegicus
-
Sprague-Dawley rat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.154 brain
-
Rattus norvegicus
-
1.14.14.154 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.14.154 0.0000084
-
brain microsomes, substrate: lanosterol Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2 best substrate Rattus norvegicus 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2 lanosta-8,24-dien-3beta-ol Rattus norvegicus 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2 4,4,14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol Rattus norvegicus 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
1.14.14.154 additional information brain microsomes, existence of sterol biosynthetic pathway in brain, cholesterol is synthesized de novo in brain Rattus norvegicus ?
-
?
1.14.14.154 additional information lanosterol 14-demethylation is situated at the root of sterol-biosynthetic branch of mevalonic acid pathway Rattus norvegicus ?
-
?
1.14.14.154 additional information enzyme of sterol biosynthetic pathway Rattus norvegicus ?
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.14.154 37
-
assay at Rattus norvegicus
1.14.14.154 37
-
aerobic conditions Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.14.154 7.5
-
assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.154 cytochrome P450
-
Rattus norvegicus
1.14.14.154 heme heme-thiolate enzyme Rattus norvegicus