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Literature summary extracted from
- Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways (1997), Drug Metab. Dispos., 26, 188-191.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.55 | etoposide | maximum inhibition of quinine 3-hydroxylation of 60% at 0.1 mM | Homo sapiens |  |
| 1.14.14.55 | ketoconazole | maximum inhibition of 90% at 0.001 mM | Homo sapiens | |
| 1.14.14.55 | Quinine | maximum inhibition of etoposide 3'-demethylation of 52% at 0.1 mM | Homo sapiens | |
| 1.14.14.55 | troleandomycin | maximum inhibition of 80% at 0.1 mM | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.14.55 | microsome | - |
Homo sapiens | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.55 | Homo sapiens | - |
human | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.55 | liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.55 | etoposide + NADPH + O2 | - |
Homo sapiens | 3'-demethyletoposide + NADP+ + H2O | - |
? | |
| 1.14.14.55 | quinine + NADPH + O2 | - |
Homo sapiens | 3-hydroxyquinine + NADP+ + H2O | - |
? | |
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