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Literature summary extracted from
- Sulfoxidation of albendazole by a cytochrome P450-independent monooxygenase from rat liver microsomes (1986), Vet. Res. Commun., 10, 317-324.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.32 | thiobenzamide | - |
Rattus norvegicus |  |
| 1.14.13.32 | tranylcypromine | competitive inhibitor | Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.13.32 | 0.0536 | - |
albendazole | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.13.32 | endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
| 1.14.13.32 | endoplasmic reticulum | - |
Sus scrofa | 5783 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.13.32 | albendazole + NADPH + O2 | Rattus norvegicus | - |
albendazole S-oxide + NADP+ + H2O | - |
? | |
| 1.14.13.32 | albendazole + NADPH + O2 | Sus scrofa | - |
albendazole S-oxide + NADP+ + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.13.32 | Rattus norvegicus | - |
- |
- |
| 1.14.13.32 | Sus scrofa | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.13.32 | liver | - |
Rattus norvegicus | - |
| 1.14.13.32 | liver | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.14.13.32 | 0.00059 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.13.32 | albendazole + NADPH + O2 | - |
Rattus norvegicus | albendazole S-oxide + NADP+ + H2O | - |
? | |
| 1.14.13.32 | albendazole + NADPH + O2 | - |
Sus scrofa | albendazole S-oxide + NADP+ + H2O | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.13.32 | 7.4 | - |
assay conditions | Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.32 | FAD | flavoprotein, flavin-containing monooxygenase | Rattus norvegicus | |
| 1.14.13.32 | FAD | flavoprotein, flavin-containing monooxygenase | Sus scrofa | |
| 1.14.13.32 | NADPH | - |
Rattus norvegicus | |
| 1.14.13.32 | NADPH | - |
Sus scrofa | |
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