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Literature summary extracted from

  • Croes, K.; Foulon, V.; Casteels, M.; Van Veldhoven, P.P.; Mannaerts, G.P.
    Phytanoyl-CoA hydroxylase: recognition of 3-methyl-branched acyl-CoAs and requirement for GTP or ATP and Mg2+ in addition to its known hydroxylation cofactors (2000), J. Lipid Res., 41, 629-636.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.11.18 in bacterial expression vector pQE-31 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.11.18 2-methylhexadecanoyl-CoA 56% of control activity Homo sapiens
1.14.11.18 hexadecanoyl-CoA 74% of control activity Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.18 Fe2+ requirement Homo sapiens
1.14.11.18 Fe2+ requirement Rattus norvegicus
1.14.11.18 Mg2+
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.18 Homo sapiens
-
 human
-
1.14.11.18 Rattus norvegicus
-
 rat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.18 liver
-
 Homo sapiens
-
1.14.11.18 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.18 3-methylhexadecanoyl-CoA + 2-oxoglutarate + O2
-
 Homo sapiens 2-hydroxy-3-methylhexadecanoyl-CoA + succinate + CO2
-
 ?
1.14.11.18 3-methylhexadecanoyl-CoA + 2-oxoglutarate + O2
-
 Rattus norvegicus 2-hydroxy-3-methylhexadecanoyl-CoA + succinate + CO2
-
 ?
1.14.11.18 phytanoyl-CoA + 2-oxoglutarate + O2
-
 Rattus norvegicus alpha-hydroxyphytanoyl-CoA + succinate + CO2
-
 ?
1.14.11.18 phytanoyl-CoA + 2-oxoglutarate + O2 no activity with octadecanoyl-CoA, lignoceroyl-CoA, 2-methylhexadecanoyl-CoA and 4,8,12-trimethyltridecanoyl-CoA Homo sapiens alpha-hydroxyphytanoyl-CoA + succinate + CO2
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.11.18 ATP
-
 Homo sapiens
1.14.11.18 ATP
-
 Rattus norvegicus
1.14.11.18 GTP
-
 Homo sapiens
1.14.11.18 additional information UTP, CTP, ITP, AMP, ADP, NAD+ and FAD can not act as cofactors, ATP and GTP can be replaced by adenosine-5'-O-(3-thiotriphosphate), adenylylimidodiphosphate, adenylyl-(beta,gamma-methylene)-diphosphonate and guanylyl-imidodiphosphate Homo sapiens