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Literature summary extracted from

  • Zomer, A.W.M.; Jansen, G.A.; Van der Burg, B.; Verhoeven, N.M.; Jakobs, C.; Van der Saag, P.T.; Wanders, R.J.A.; Poll-The, B.T.
    Phytanoyl-CoA hydroxylase activity is induced by phytanic acid (2000), Eur. J. Biochem., 267, 4063-4067.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.18 Homo sapiens
-
 human
-
1.14.11.18 Mus musculus
-
 mouse
-
1.14.11.18 Platyrrhini
-
-
-
1.14.11.18 Rattus norvegicus
-
 rat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.18 embryonic cell line embryonic carcinoma cell line Mus musculus
-
1.14.11.18 hepatoma cell line
-
 Homo sapiens
-
1.14.11.18 hepatoma cell line
-
 Rattus norvegicus
-
1.14.11.18 kidney
-
 Homo sapiens
-
1.14.11.18 kidney
-
 Platyrrhini
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.11.18 0.000001
-
 in kidney cell line COS-1, activity can be induced 4fold by phytanic acid Platyrrhini
1.14.11.18 0.0000018
-
 in embryonic carcinoma cell line P19-EC, activity can be induced 4fold by phytanic acid Mus musculus
1.14.11.18 0.000002
-
 in kidney cell line 293, activity can be induced 4fold by phytanic acid Homo sapiens
1.14.11.18 0.0000031
-
 in hepatoma cell line HepG2, no induction by phytanic acid Homo sapiens
1.14.11.18 0.000024
-
 in hepatoma cell line FaO, activity can be induced 2.5fold by phytanic acid Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.18 phytanoyl-CoA + 2-oxoglutarate + O2
-
 Homo sapiens alpha-hydroxyphytanoyl-CoA + succinate + CO2
-
 ?
1.14.11.18 phytanoyl-CoA + 2-oxoglutarate + O2
-
 Rattus norvegicus alpha-hydroxyphytanoyl-CoA + succinate + CO2
-
 ?