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Literature summary extracted from
- Characterization of phytanoyl-Coenzyme A hydroxylase in human liver and activity measurements in patients with peroxisomal disorders (1998), Clin. Chim. Acta, 271, 203-211.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.11.18 | ascorbate | 2.5fold induction at 5 mM | Homo sapiens |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.11.18 | additional information | not inhibited by bifonazole, clotrimazole, miconazole, ketoconazole | Homo sapiens | |
| 1.14.11.18 | propyl gallate | no activity with 1 mM, interacts with iron binding | Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.11.18 | 0.049 | - |
2-oxoglutarate | - |
Homo sapiens | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.11.18 | Fe2+ | requirement | Homo sapiens | |
| 1.14.11.18 | Fe2+ | optimal activity at 0.5 mM | Homo sapiens | |
| 1.14.11.18 | additional information | Cu2+, Mn2+ or Zn2+ can not replace Fe2+ | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.11.18 | Homo sapiens | - |
human | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.11.18 | liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.14.11.18 | 0.000041 | - |
in liver homogenate | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.11.18 | phytanoyl-CoA + 2-oxoglutarate + O2 | - |
Homo sapiens | alpha-hydroxyphytanoyl-CoA + succinate + CO2 | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.11.18 | 7.5 | - |
- |
Homo sapiens |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.11.18 | 6.5 | 8.5 | at pH 6.5 over 80%, at pH 8.5 50% of control activity | Homo sapiens |
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Release 2023.1 (January 2023)
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