BRENDA - Enzyme Database

The inhibition and activation of Ca2+-dependent phosphatidylinositol phosphodiesterase by phospholipids and blood plasma

Dawson, R.M.C.; Hemington, N.; Irvine, R.F.; Eur. J. Biochem. 112, 33-38 (1980)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.4.11
decanoylglycerophosphate
only little activating effect
Rattus norvegicus
3.1.4.11
decanoyllysophosphatidylcholine
C10 lysophosphatidylcholine activates the reaction
Rattus norvegicus
3.1.4.11
dihexanoylglycerophosphocholine
-
Rattus norvegicus
3.1.4.11
oleoylglycerophosphate
activates the hydrolysis at a physiological pH
Rattus norvegicus
3.1.4.11
palmitoylglycerophosphate
activates the hydrolysis at a physiological pH
Rattus norvegicus
3.1.4.11
phosphatidic acid
activates the hydrolysis at a physiological pH
Rattus norvegicus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.4.11
Blood lipoprotein
enzyme is strongly inhibited by blood plasma, serum and blood lipoproteins
Rattus norvegicus
3.1.4.11
Blood plasma
enzyme is strongly inhibited by blood plasma, serum and blood lipoproteins
Rattus norvegicus
3.1.4.11
Blood serum
enzyme is strongly inhibited by blood plasma, serum and blood lipoproteins
Rattus norvegicus
3.1.4.11
lysophosphatidylcholine
C12, C14 and C16 lysophosphatidylcholines give progressive inhibition with increasing chain length
Rattus norvegicus
3.1.4.11
phosphatidylcholine
the enzyme is strongly inhibited when ovophosphatidylcholine and saturated phosphatidylcholines with acyl chain length of more than eight carbon atoms are mixed with its substrate
Rattus norvegicus
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.4.11
Ca2+
required
Rattus norvegicus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.4.11
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.4.11
brain
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.4.11
phosphatidylinositol + H2O
-
285224
Rattus norvegicus
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.4.11
decanoylglycerophosphate
only little activating effect
Rattus norvegicus
3.1.4.11
decanoyllysophosphatidylcholine
C10 lysophosphatidylcholine activates the reaction
Rattus norvegicus
3.1.4.11
dihexanoylglycerophosphocholine
-
Rattus norvegicus
3.1.4.11
oleoylglycerophosphate
activates the hydrolysis at a physiological pH
Rattus norvegicus
3.1.4.11
palmitoylglycerophosphate
activates the hydrolysis at a physiological pH
Rattus norvegicus
3.1.4.11
phosphatidic acid
activates the hydrolysis at a physiological pH
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.4.11
Blood lipoprotein
enzyme is strongly inhibited by blood plasma, serum and blood lipoproteins
Rattus norvegicus
3.1.4.11
Blood plasma
enzyme is strongly inhibited by blood plasma, serum and blood lipoproteins
Rattus norvegicus
3.1.4.11
Blood serum
enzyme is strongly inhibited by blood plasma, serum and blood lipoproteins
Rattus norvegicus
3.1.4.11
lysophosphatidylcholine
C12, C14 and C16 lysophosphatidylcholines give progressive inhibition with increasing chain length
Rattus norvegicus
3.1.4.11
phosphatidylcholine
the enzyme is strongly inhibited when ovophosphatidylcholine and saturated phosphatidylcholines with acyl chain length of more than eight carbon atoms are mixed with its substrate
Rattus norvegicus
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.4.11
Ca2+
required
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.4.11
brain
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.4.11
phosphatidylinositol + H2O
-
285224
Rattus norvegicus
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
?