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Literature summary extracted from

  • Sies, W.; Lapetina, E.G.
    Properties and distribution of phosphatidylinositol-specific phospholipase C in human and horse platelets (1983), Biochim. Biophys. Acta, 752, 329-338.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.11 deoxycholate weak inhibition. Concentration of 2 mM inhibits the phospholipase C activity in all fractions by 20-30% Equus caballus
3.1.4.11 deoxycholate weak inhibition. Concentration of 2 mM inhibits the phospholipase C activity in all fractions by 20-30% Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.11 0.1 0.15 1-phosphatidyl-1D-myo-inositol
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.11 additional information enzyme is predominantly localized in the soluble fraction Homo sapiens
-
-
3.1.4.11 additional information enzyme is predominantly localized in the soluble fraction Equus caballus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.11 Ca2+ dependent on Homo sapiens
3.1.4.11 Ca2+ dependend on Equus caballus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.11 Equus caballus
-
-
-
3.1.4.11 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.11 blood platelet homogenates, total particulate and soluble fractions Homo sapiens
-
3.1.4.11 blood platelet homogenates, total particulate and soluble fractions Equus caballus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.11 1-phosphatidyl-1D-myo-inositol
-
 Equus caballus 1D-myo-inositol 1-phosphate + diacylglycerol in almost equal amounts with 1D-myo-inositol 1,2-cyclic phosphate ?
3.1.4.11 1-phosphatidyl-1D-myo-inositol + H2O
-
 Homo sapiens 1D-myo-inositol 1-phosphate + diacylglycerol in almost equal amounts with 1D-myo-inositol 1,2-cyclic phosphate ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.11 phospholipase C
-
 Homo sapiens
3.1.4.11 phospholipase C
-
 Equus caballus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.11 5.5
-
-
 Homo sapiens
3.1.4.11 5.5
-
-
 Equus caballus