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Literature summary extracted from
- Characterization of rat kidney proximal tubule brush border membrane-associated phosphatidylinositol phosphodiesterase (1983), Arch. Biochem. Biophys., 224, 555-567.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.11 | deoxycholate | - |
Rattus norvegicus |  |
| 3.1.4.11 | additional information | sodium lauryl sulfate, tetradecyl-trimethylammonium bromide, and Triton X-100 do not activate phosphatidylinositol phosphodiesterase in the presence of Ca2+ | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.11 | ATP | 1-5 mM | Rattus norvegicus | |
| 3.1.4.11 | HgCl2 | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.4.11 | membrane | associated | Rattus norvegicus | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.11 | Ca2+ | stimulates | Rattus norvegicus | |
| 3.1.4.11 | Mg2+ | stimulates | Rattus norvegicus | |
| 3.1.4.11 | Mn2+ | stimulates | Rattus norvegicus | |
| 3.1.4.11 | additional information | Ba2+, Zn2+, Hg2+, K+ are ineffective | Rattus norvegicus | |
| 3.1.4.11 | additional information | certain divalent cations are necessary for enzyme activity | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.11 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.4.11 | kidney | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.11 | phosphatidylinositol + H2O | enzyme is specific for phosphatidylinositol | Rattus norvegicus | diacylglycerol + 1D-myo-inositol 1-phosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.4.11 | phosphatidylinositol phosphodiesterase | - |
Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.11 | 7 | 8.5 | - |
Rattus norvegicus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.11 | 6 | 11 | pH: 6.0: about 10% of maximal activity, pH 11.0: about 40% of maximal activity | Rattus norvegicus |
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Release 2023.1 (January 2023)
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